TY - JOUR
T1 - Pathophysiology of aortic valve stenosis
T2 - Is it both fibrocalcific and sex specific?
AU - Sritharen, Yoginee
AU - Enriquez-Sarano, Maurice
AU - Schaff, Hartzell V.
AU - Casaclang-Verzosa, Grace
AU - Miller, Jordan D.
N1 - Publisher Copyright:
© 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2017/5
Y1 - 2017/5
N2 - Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
AB - Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
UR - http://www.scopus.com/inward/record.url?scp=85018819770&partnerID=8YFLogxK
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U2 - 10.1152/physiol.00025.2016
DO - 10.1152/physiol.00025.2016
M3 - Review article
C2 - 28404735
AN - SCOPUS:85018819770
SN - 1548-9213
VL - 32
SP - 182
EP - 196
JO - Physiology
JF - Physiology
IS - 3
ER -