Pathophysiology of aortic valve stenosis: Is it both fibrocalcific and sex specific?

Yoginee Sritharen, Maurice Enriquez-Sarano, Hartzell V. Schaff, Grace Casaclang-Verzosa, Jordan D. Miller

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.

Original languageEnglish (US)
Pages (from-to)182-196
Number of pages15
JournalPhysiology
Volume32
Issue number3
DOIs
StatePublished - May 2017

ASJC Scopus subject areas

  • Physiology

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