Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea

Michael Camilleri, Joseph H. Sellin, Kim E. Barrett

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Chronic watery diarrhea poses a diagnostic and therapeutic challenge and is often a disabling condition for patients. Although acute diarrhea is likely to be caused by infection, the causes of chronic diarrhea (>4 weeks in duration) are more elusive. We review the pathophysiology, diagnosis, and treatment of chronic diarrhea. Drawing on recent insights into the molecular mechanisms of intestinal epithelial transport and barrier function, we discuss how diarrhea can result from a decrease in luminal solute absorption, an increase in secretion, or both, as well as derangements in barrier properties. We also describe the various extraepithelial factors that activate diarrheal mechanisms. Finally, clinical evaluation and tests used in the assessment of patients presenting with chronic diarrhea are reviewed, and an algorithm guiding therapeutic decisions and pharmacotherapy is presented.

Original languageEnglish (US)
Pages (from-to)515-532.e2
JournalGastroenterology
Volume152
Issue number3
DOIs
StatePublished - Feb 1 2017

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Diarrhea
Therapeutics
Drug Therapy
Infection

Keywords

  • Diarrhea
  • Management
  • Pathophysiology

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. / Camilleri, Michael; Sellin, Joseph H.; Barrett, Kim E.

In: Gastroenterology, Vol. 152, No. 3, 01.02.2017, p. 515-532.e2.

Research output: Contribution to journalReview article

Camilleri, Michael ; Sellin, Joseph H. ; Barrett, Kim E. / Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. In: Gastroenterology. 2017 ; Vol. 152, No. 3. pp. 515-532.e2.
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