Pathophysiological basis of orthostatic hypotension in autonomic failure

Adrianus A J Smit, John R. Halliwill, Phillip Anson Low, Wouter Wieling

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

In patients with autonomic failure orthostatic hypotension results from an impaired capacity to increase vascular resistance during standing. This fundamental defect leads to increased downward pooling of venous blood and a consequent reduction in stroke volume and cardiac output that exaggerates the orthostatic fall in blood pressure. The location of excessive venous blood pooling has not been established so far, but present data suggest that the abdominal compartment and perhaps leg skin vasculature are the most likely candidates. To improve the orthostatic tolerance in patients with autonomic failure, protective measures that reduce excessive orthostatic blood pooling have been developed and evaluated. These measures include physical counter-manoeuvres and abdominal compression.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Physiology
Volume519
Issue number1
DOIs
StatePublished - Aug 15 1999

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Orthostatic Hypotension
Cardiac Output
Vascular Resistance
Stroke Volume
Leg
Blood Pressure
Skin

ASJC Scopus subject areas

  • Physiology

Cite this

Pathophysiological basis of orthostatic hypotension in autonomic failure. / Smit, Adrianus A J; Halliwill, John R.; Low, Phillip Anson; Wieling, Wouter.

In: Journal of Physiology, Vol. 519, No. 1, 15.08.1999, p. 1-10.

Research output: Contribution to journalArticle

Smit, Adrianus A J ; Halliwill, John R. ; Low, Phillip Anson ; Wieling, Wouter. / Pathophysiological basis of orthostatic hypotension in autonomic failure. In: Journal of Physiology. 1999 ; Vol. 519, No. 1. pp. 1-10.
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