@article{9c55f743d0954598be4e317efb250182,
title = "Pathophysiologic features of episodic gonadotropin secretion in man",
abstract = "Endocrine glands typically signal their remote target tissues by an intermittent, rather than an invariant, pattern of hormone secretion. This pulsatile mode of hormone release is believed to convey significant information to the target cells. This review focuses on the luteinizing hormone pulse signal in man as a paradigm for endocrine glandular signaling in general. In particular, recent developments in our understanding of the pathophysiology of luteinizing hormone secretion in men and women is examined, and illustrate how specific disturbances in neuroendocrine physiology can result in altered reproductive states are illustrated. New models of pituitary-secretory dynamics that are likely to help clarify more subtle defects in fertility regulation in man and experimental animals are suggested.",
author = "Veldhuis, {J. D.}",
note = "Funding Information: From the Division of Endocrinology and Metabolism, Depart· ment of Internal Medicine, University of Virginia School of Medi· cine, Charlottesville, Virginia. Supported in part by NIH grant No. RR 00847 to the Clinical Research Center of the University of VirgiT/ia, by RCDA #1 K04 HD 00634, Diabetes and Research Training Center Grant #5 P60 AM 22125-05, and NIH ·supported Clinfo Data Reduction Systems. The author thanks Chris McNett for her skillful preparation of the manuscript, Paula P. Azimi for the artwork, Sandra Jackson and the nursing staff at the Clinical Research Center at the U niver· sity of Virginia for excellent patient care, and Mr. David Boyd for valued assistance with Clinfo. Presented at the 1987 Annual Southern Sectional Meeting of the American Federation for Clinical Research, New Orleans, Louisi· ana, upon receipt of the SouthernAFCR Sectional Clinical Investi· gator Award. Reprint requests: Johannes D. Veldhuis, MD, Division of Endocrinology and Metabolism, Department of I nternal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908.",
year = "1987",
doi = "10.1097/00000441-198709000-00005",
language = "English (US)",
volume = "294",
pages = "150--160",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}