Pathology of multiple myeloma

Dragan Jevremovic, William Morice

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple myeloma (MM) and other plasma cell proliferative disorders (PCPD) are a group of systemic diseases which share as a unifying feature the presence of clonal plasma cells. As described in previous chapters, bone marrow is the most common tissue involved, but the neoplastic plasma cells may be found in virtually any tissue/organ. While serum protein electrophoresis and free light chain analysis are essential in early detection and follow-up, the pathologic diagnosis of MM and other PCPD is made on the bone marrow aspirate and biopsy specimen [1]. The goal of the pathologic examination of the bone marrow is to: (a) quantify bone marrow plasma cells (necessary WHO criteria for the diagnosis of MM); (b) establish PC clonality; (c) distinguish MM from lymphoplasmacytic lymphoma (LPL) and other B-cell lymphomas with plasmacytic differentiation; (d) analyze prognostic factors; (e) detect amyloid deposits; and (f) detect other potential pathologic processes, in lymphoid and myeloid compartments.

Original languageEnglish (US)
Title of host publicationMultiple Myeloma
Subtitle of host publicationDiagnosis and Treatment
PublisherSpringer New York
Pages27-34
Number of pages8
ISBN (Electronic)9781461485209
ISBN (Print)9781461485193
DOIs
StatePublished - Jan 1 2014

Fingerprint

Plasma Cells
Multiple Myeloma
Pathology
Bone Marrow
Bone Marrow Examination
Amyloid Plaques
B-Cell Lymphoma
Pathologic Processes
Bone Marrow Cells
Electrophoresis
Blood Proteins
Lymphoma
Biopsy
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jevremovic, D., & Morice, W. (2014). Pathology of multiple myeloma. In Multiple Myeloma: Diagnosis and Treatment (pp. 27-34). Springer New York. https://doi.org/10.1007/978-1-4614-8520-9_3

Pathology of multiple myeloma. / Jevremovic, Dragan; Morice, William.

Multiple Myeloma: Diagnosis and Treatment. Springer New York, 2014. p. 27-34.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jevremovic, D & Morice, W 2014, Pathology of multiple myeloma. in Multiple Myeloma: Diagnosis and Treatment. Springer New York, pp. 27-34. https://doi.org/10.1007/978-1-4614-8520-9_3
Jevremovic D, Morice W. Pathology of multiple myeloma. In Multiple Myeloma: Diagnosis and Treatment. Springer New York. 2014. p. 27-34 https://doi.org/10.1007/978-1-4614-8520-9_3
Jevremovic, Dragan ; Morice, William. / Pathology of multiple myeloma. Multiple Myeloma: Diagnosis and Treatment. Springer New York, 2014. pp. 27-34
@inbook{2c93b3d8939943d29455b8804960c10a,
title = "Pathology of multiple myeloma",
abstract = "Multiple myeloma (MM) and other plasma cell proliferative disorders (PCPD) are a group of systemic diseases which share as a unifying feature the presence of clonal plasma cells. As described in previous chapters, bone marrow is the most common tissue involved, but the neoplastic plasma cells may be found in virtually any tissue/organ. While serum protein electrophoresis and free light chain analysis are essential in early detection and follow-up, the pathologic diagnosis of MM and other PCPD is made on the bone marrow aspirate and biopsy specimen [1]. The goal of the pathologic examination of the bone marrow is to: (a) quantify bone marrow plasma cells (necessary WHO criteria for the diagnosis of MM); (b) establish PC clonality; (c) distinguish MM from lymphoplasmacytic lymphoma (LPL) and other B-cell lymphomas with plasmacytic differentiation; (d) analyze prognostic factors; (e) detect amyloid deposits; and (f) detect other potential pathologic processes, in lymphoid and myeloid compartments.",
author = "Dragan Jevremovic and William Morice",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-1-4614-8520-9_3",
language = "English (US)",
isbn = "9781461485193",
pages = "27--34",
booktitle = "Multiple Myeloma",
publisher = "Springer New York",

}

TY - CHAP

T1 - Pathology of multiple myeloma

AU - Jevremovic, Dragan

AU - Morice, William

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Multiple myeloma (MM) and other plasma cell proliferative disorders (PCPD) are a group of systemic diseases which share as a unifying feature the presence of clonal plasma cells. As described in previous chapters, bone marrow is the most common tissue involved, but the neoplastic plasma cells may be found in virtually any tissue/organ. While serum protein electrophoresis and free light chain analysis are essential in early detection and follow-up, the pathologic diagnosis of MM and other PCPD is made on the bone marrow aspirate and biopsy specimen [1]. The goal of the pathologic examination of the bone marrow is to: (a) quantify bone marrow plasma cells (necessary WHO criteria for the diagnosis of MM); (b) establish PC clonality; (c) distinguish MM from lymphoplasmacytic lymphoma (LPL) and other B-cell lymphomas with plasmacytic differentiation; (d) analyze prognostic factors; (e) detect amyloid deposits; and (f) detect other potential pathologic processes, in lymphoid and myeloid compartments.

AB - Multiple myeloma (MM) and other plasma cell proliferative disorders (PCPD) are a group of systemic diseases which share as a unifying feature the presence of clonal plasma cells. As described in previous chapters, bone marrow is the most common tissue involved, but the neoplastic plasma cells may be found in virtually any tissue/organ. While serum protein electrophoresis and free light chain analysis are essential in early detection and follow-up, the pathologic diagnosis of MM and other PCPD is made on the bone marrow aspirate and biopsy specimen [1]. The goal of the pathologic examination of the bone marrow is to: (a) quantify bone marrow plasma cells (necessary WHO criteria for the diagnosis of MM); (b) establish PC clonality; (c) distinguish MM from lymphoplasmacytic lymphoma (LPL) and other B-cell lymphomas with plasmacytic differentiation; (d) analyze prognostic factors; (e) detect amyloid deposits; and (f) detect other potential pathologic processes, in lymphoid and myeloid compartments.

UR - http://www.scopus.com/inward/record.url?scp=84956485484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956485484&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-8520-9_3

DO - 10.1007/978-1-4614-8520-9_3

M3 - Chapter

AN - SCOPUS:84956485484

SN - 9781461485193

SP - 27

EP - 34

BT - Multiple Myeloma

PB - Springer New York

ER -