Pathological markers associated with normal aging and dementia in the elderly

Howard A. Crystal, Dennis W Dickson, Martin J. Sliwinski, Richard B. Lipton, Ellen Grober, Harriet Marks-Nelson, Phyllis Antis

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 ± 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocam-pal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.

Original languageEnglish (US)
Pages (from-to)566-573
Number of pages8
JournalAnnals of Neurology
Volume34
Issue number4
StatePublished - Oct 1993
Externally publishedYes

Fingerprint

Vascular Dementia
Dementia
Amyloid Plaques
Alzheimer Disease
Leukoencephalopathies
Lewy Bodies
Lewy Body Disease
Cognition
Multiple Sclerosis
Age Groups
Pathology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks-Nelson, H., & Antis, P. (1993). Pathological markers associated with normal aging and dementia in the elderly. Annals of Neurology, 34(4), 566-573.

Pathological markers associated with normal aging and dementia in the elderly. / Crystal, Howard A.; Dickson, Dennis W; Sliwinski, Martin J.; Lipton, Richard B.; Grober, Ellen; Marks-Nelson, Harriet; Antis, Phyllis.

In: Annals of Neurology, Vol. 34, No. 4, 10.1993, p. 566-573.

Research output: Contribution to journalArticle

Crystal, HA, Dickson, DW, Sliwinski, MJ, Lipton, RB, Grober, E, Marks-Nelson, H & Antis, P 1993, 'Pathological markers associated with normal aging and dementia in the elderly', Annals of Neurology, vol. 34, no. 4, pp. 566-573.
Crystal HA, Dickson DW, Sliwinski MJ, Lipton RB, Grober E, Marks-Nelson H et al. Pathological markers associated with normal aging and dementia in the elderly. Annals of Neurology. 1993 Oct;34(4):566-573.
Crystal, Howard A. ; Dickson, Dennis W ; Sliwinski, Martin J. ; Lipton, Richard B. ; Grober, Ellen ; Marks-Nelson, Harriet ; Antis, Phyllis. / Pathological markers associated with normal aging and dementia in the elderly. In: Annals of Neurology. 1993 ; Vol. 34, No. 4. pp. 566-573.
@article{95bb8bc0ee30499ebf0e9d5809a0b8c8,
title = "Pathological markers associated with normal aging and dementia in the elderly",
abstract = "We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 ± 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocam-pal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40{\%} of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.",
author = "Crystal, {Howard A.} and Dickson, {Dennis W} and Sliwinski, {Martin J.} and Lipton, {Richard B.} and Ellen Grober and Harriet Marks-Nelson and Phyllis Antis",
year = "1993",
month = "10",
language = "English (US)",
volume = "34",
pages = "566--573",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Pathological markers associated with normal aging and dementia in the elderly

AU - Crystal, Howard A.

AU - Dickson, Dennis W

AU - Sliwinski, Martin J.

AU - Lipton, Richard B.

AU - Grober, Ellen

AU - Marks-Nelson, Harriet

AU - Antis, Phyllis

PY - 1993/10

Y1 - 1993/10

N2 - We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 ± 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocam-pal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.

AB - We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 ± 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocam-pal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.

UR - http://www.scopus.com/inward/record.url?scp=0027432101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027432101&partnerID=8YFLogxK

M3 - Article

C2 - 8215244

AN - SCOPUS:0027432101

VL - 34

SP - 566

EP - 573

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -