Pathological and clinical characterization of the 'Troubled transplant': Data from the DeKAF study

S. Gourishankar, R. Leduc, J. Connett, J. M. Cecka, F. Cosio, A. Fieberg, R. Gaston, P. Halloran, L. Hunsicker, B. Kasiske, D. Rush, J. Grande, R. Mannon, A. Matas

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

We are studying two cohorts of kidney transplant recipients, with the goal of defining specific clinicopathologic entities that cause late graft dysfunction: (1) prevalent patients with new onset late graft dysfunction (cross-sectional cohort); and (2) newly transplanted patients (prospective cohort). For the cross-sectional cohort (n = 440), mean time from transplant to biopsy was 7.5 ± 6.1 years. Local pathology diagnoses included CAN (48%), CNI toxicity (30%), and perhaps surprisingly, acute rejection (cellular- or Ab-mediated) (23%). Actuarial rate of death-censored graft loss at 1 year postbiopsy was 17.7%; at 2 years, 29.8%. There was no difference in postbiopsy graft survival for recipients with versus without CAN (p = 0.9). Prospective cohort patients (n = 2427) developing graft dysfunction >3 months posttransplant undergo 'index' biopsy. The rate of index biopsy was 8.8% between 3 and 12 months, and 18.2% by 2 years. Mean time from transplant to index biopsy was 1.0 ± 0.6 years. Local pathology diagnoses included CAN (27%), and acute rejection (39%). Intervention to halt late graft deterioration cannot be developed in the absence of meaningful diagnostic entities. We found CAN in late posttransplant biopsies to be of no prognostic value. The DeKAF study will provide broadly applicable diagnostic information to serve as the basis for future trials.

Original languageEnglish (US)
Pages (from-to)324-330
Number of pages7
JournalAmerican Journal of Transplantation
Volume10
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Allograft function
  • Kidney transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Pathological and clinical characterization of the 'Troubled transplant': Data from the DeKAF study'. Together they form a unique fingerprint.

  • Cite this

    Gourishankar, S., Leduc, R., Connett, J., Cecka, J. M., Cosio, F., Fieberg, A., Gaston, R., Halloran, P., Hunsicker, L., Kasiske, B., Rush, D., Grande, J., Mannon, R., & Matas, A. (2010). Pathological and clinical characterization of the 'Troubled transplant': Data from the DeKAF study. American Journal of Transplantation, 10(2), 324-330. https://doi.org/10.1111/j.1600-6143.2009.02954.x