Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma

Xian shu Gao, Xueying Qiao, Fengpeng Wu, Li Cao, Xianli Meng, Zhiming Dong, Xiaoling Wang, Guodong Gao, Tsung Teh Wu, Ritsuko Komaki, Joe Y. Chang

Research output: Contribution to journalArticle

81 Scopus citations


Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. Methods and Materials: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node (LN) metastasis. Results: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 ± 13.5 mm proximally (<30 mm in 32 of 34 cases) and 10.6 ± 8.1 mm distally (<30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 ± 7.2 mm proximally (<30 mm in 29 of 29 cases) and 18.3 ± 16.3 mm distally (<30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (p = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma. Conclusions: The extent of microscopic spread within esophagus (recommended CTV margin) was <30 mm in about 94% of cases of esophageal cancer, except for distal microscopic spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases.

Original languageEnglish (US)
Pages (from-to)389-396
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number2
StatePublished - Feb 1 2007



  • Adenocarcinoma of gastroesophageal junction
  • Clinical target volume
  • Esophageal carcinoma
  • Esophagectomy
  • Lymph node metastasis
  • Microscopic spread

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this