Abstract
Immunoglobulin(Ig)G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect virtually any organ and usually presents as tumefactive lesions involving multiple sites. Characteristic histopathology of IgG4-RD consists of dense lymphoplasmacytic infiltrate, fibrosis (often in storiform pattern), and obliterative phlebitis, accompanied by tissue infiltration of IgG4-positive plasma cells with or without elevation of serum IgG4 level. Despite a general similarity in the morphologic manifestations of IgG4-RD, site-specific unique morphologic features have been described in some organs including the lung. Compared with other sites, pulmonary involvement by IgG4-RD has been recognized more recently, and lung biopsy interpretation for this condition is often challenging, as both a relative paucity of pathognomonic features and a plethora of overlapping findings with other fibroinflammatory processes of the lung. This review is focused on the morphologic spectrum of IgG4-related lung disease documented in the current literature and on the pertinent issues in the differential diagnoses with other conditions encountered in the lung.
Original language | English (US) |
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Pages (from-to) | 219-225 |
Number of pages | 7 |
Journal | Seminars in Diagnostic Pathology |
Volume | 29 |
Issue number | 4 |
DOIs | |
State | Published - Nov 2012 |
Keywords
- Histopathology;
- Immunoglobulin(Ig)G4;
- Lung;
- Lymphoma;
- Rosai-Dorfman disease
- Thorax;
ASJC Scopus subject areas
- Pathology and Forensic Medicine