Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type

Paul J. Kurtin, Jeffrey L. Myers, Hakiran Adlakha, John G. Strickler, Christine Lohse, V. Shane Pankratz, David J. Inwards

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

We reviewed pathologic, phenotypic, and clinical features of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type primarily involving lung to address unresolved questions regarding behavior and pathologic features of unambiguously diagnosed pulmonary MALT lymphoma. Lung specimens from 50 patients were reviewed, Forty-one had low-grade MALT lymphoma. Nine had low-grade MALT lymphoma and diffuse large B-cell lymphoma. The patients included 32 women and 18 men with a median age of 68 years (range 34-88 years). Half of the patients were asymptomatic at the time lymphoma was diagnosed. Radiographic abnormalities were more commonly unilateral (37 patients) than bilateral (12 patients). Localized masses or nodules occurred in 39 patients. Associated autoimmune disorders (29%) and monoclonal gammopathies (43%) were common. Low-grade lymphomas formed intraparenchymal masses composed of centrocyte-like cells, plasmacytoid lymphocytes, and plasma cells that formed lymphoepithelial lesions and exhibited a lymphangitic growth pattern. Mediastinal lymph nodes were involved histologically in 44% of cases. Lymphoma-specific survival was 71.7% at 10 years, and overall survival was significantly worse than age- and gender-matched control patients. None of the following features predicted those patients who had an adverse outcome: systemic symptoms, presence of autoimmune disorders or paraproteinemia, anatomic distribution and number of pulmonary lesions, lymph node involvement, or presence of anthracycline-treated large B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)997-1008
Number of pages12
JournalAmerican Journal of Surgical Pathology
Volume25
Issue number8
DOIs
StatePublished - 2001

Fingerprint

Marginal Zone B-Cell Lymphoma
Lung
Non-Hodgkin's Lymphoma
Paraproteinemias
Lymphoma
Lymph Nodes
Survival
Lymphoma, Large B-Cell, Diffuse
Anthracyclines
B-Cell Lymphoma
Plasma Cells
Lymphocytes
Growth

Keywords

  • B-cell lymphoma
  • Extranodal
  • Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type
  • Lung

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Kurtin, P. J., Myers, J. L., Adlakha, H., Strickler, J. G., Lohse, C., Pankratz, V. S., & Inwards, D. J. (2001). Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. American Journal of Surgical Pathology, 25(8), 997-1008. https://doi.org/10.1097/00000478-200108000-00003

Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. / Kurtin, Paul J.; Myers, Jeffrey L.; Adlakha, Hakiran; Strickler, John G.; Lohse, Christine; Pankratz, V. Shane; Inwards, David J.

In: American Journal of Surgical Pathology, Vol. 25, No. 8, 2001, p. 997-1008.

Research output: Contribution to journalArticle

Kurtin, PJ, Myers, JL, Adlakha, H, Strickler, JG, Lohse, C, Pankratz, VS & Inwards, DJ 2001, 'Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type', American Journal of Surgical Pathology, vol. 25, no. 8, pp. 997-1008. https://doi.org/10.1097/00000478-200108000-00003
Kurtin, Paul J. ; Myers, Jeffrey L. ; Adlakha, Hakiran ; Strickler, John G. ; Lohse, Christine ; Pankratz, V. Shane ; Inwards, David J. / Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. In: American Journal of Surgical Pathology. 2001 ; Vol. 25, No. 8. pp. 997-1008.
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