Pathogenetic mechanisms in chronic myeloproliferative disorders: Polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, and chronic myelogenous leukemia

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

The stem cell origination of the clonal process in chronic myeloproliferative disorders (CMPDs) is well established. In chronic myelogenous leukemia (CML), the primary genetic process has been characterized. However, current information regarding the mechanisms of phenotypic diversity among the CMPD and the downstream effects of the cbromosomal translocation in CML remains inconclusive. In this report, the current understanding regarding erythrocytosis in polycythemia vera (PV), thrombocytosis in essential thrombocythemia (ET), bone marrow fibrosis (BMF) in agnogenic myeloid metaplasia (AMM), and the connection between the genetic alteration and cellular transformation in CML will be discussed.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalSeminars in Hematology
Volume36
Issue numberSUPPL. 2
StatePublished - Jan 28 1999

ASJC Scopus subject areas

  • Hematology

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