Pathogenesis of varicose veins

Rahmi Oklu; Roy Habito; Manuel Mayr; Amy R. Deipolyi; Hassan Albadawi; Robin Hesketh; T. Gregory Walker; Katy R. Linskey; Chandler A. Long; Stephan Wicky; Julianne Stoughton; Michael T. Watkins

doi:10.1016/j.jvir.2011.09.010

Pathogenesis of varicose veins

Rahmi Oklu, Roy Habito, Manuel Mayr, Amy R. Deipolyi, Hassan Albadawi, Robin Hesketh, T. Gregory Walker, Katy R. Linskey, Chandler A. Long, Stephan Wicky, Julianne Stoughton, Michael T. Watkins

Diagnostic Radiology

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.

Original language	English (US)
Pages (from-to)	33-39
Number of pages	7
Journal	Journal of Vascular and Interventional Radiology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.jvir.2011.09.010
State	Published - Jan 2012

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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title = "Pathogenesis of varicose veins",

abstract = "Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.",

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AU - Oklu, Rahmi

AU - Habito, Roy

AU - Mayr, Manuel

AU - Deipolyi, Amy R.

AU - Albadawi, Hassan

AU - Hesketh, Robin

AU - Walker, T. Gregory

AU - Linskey, Katy R.

AU - Long, Chandler A.

AU - Wicky, Stephan

AU - Stoughton, Julianne

AU - Watkins, Michael T.

PY - 2012/1

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N2 - Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.

AB - Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.

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Pathogenesis of varicose veins

Abstract

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