Pathogenesis of idiopathic Parkinsonism

R. J. Uitti, D. B. Caine

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Idiopathic parkinsonism (Parkinson's disease) makes up the largest diagnostic subgroup of patients with parkinsonism. Various hypotheses exist regarding the pathogenesis of idiopathic parkinsonism: these include genetic predilection, aging, environmental factors, oxidative stress, excitotoxicity, autoimmunity, and trauma. We suggest that the pathogenesis of idiopathic parkinsonism is likely to be multifactorial, deriving from environmental factor(s) acting upon a genetically predisposed individual. Because of the compelling evidence indicating common clinical and pathological findings in idiopathic parkinsonism, Alzheimer's disease, and amyotrophic lateral sclerosis, we believe that these conditions result from pathological processes with more similarity than diversity. A primary glutamatergic cell neocortical abnormality provides an attractive unifying explanation which may explain the overlapping abnormalities found in idiopathic parkinsonism, Alzheimer's disease, and amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)6-23
Number of pages18
JournalEuropean Neurology
Volume33
Issue numberSUPPL. 1
StatePublished - 1993
Externally publishedYes

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Parkinsonian Disorders
Amyotrophic Lateral Sclerosis
Alzheimer Disease
Pathologic Processes
Autoimmunity
Parkinson Disease
Oxidative Stress
Wounds and Injuries

Keywords

  • Idiopathic parkinsonism
  • Parkinson's disease
  • Pathogenesis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Uitti, R. J., & Caine, D. B. (1993). Pathogenesis of idiopathic Parkinsonism. European Neurology, 33(SUPPL. 1), 6-23.

Pathogenesis of idiopathic Parkinsonism. / Uitti, R. J.; Caine, D. B.

In: European Neurology, Vol. 33, No. SUPPL. 1, 1993, p. 6-23.

Research output: Contribution to journalArticle

Uitti, RJ & Caine, DB 1993, 'Pathogenesis of idiopathic Parkinsonism', European Neurology, vol. 33, no. SUPPL. 1, pp. 6-23.
Uitti RJ, Caine DB. Pathogenesis of idiopathic Parkinsonism. European Neurology. 1993;33(SUPPL. 1):6-23.
Uitti, R. J. ; Caine, D. B. / Pathogenesis of idiopathic Parkinsonism. In: European Neurology. 1993 ; Vol. 33, No. SUPPL. 1. pp. 6-23.
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