Pathogenesis of idiopathic parkinsonism

Ryan J. Uitli, Donald B. Caine

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Idiopathic parkinsonism (Parkinson's disease) makes up the largest diagnostic subgroup of patients with parkinsonism. Various hypotheses exist regarding the pathogenesis of idiopathic parkinsonism: these include genetic predilec-tion, aging, environmental factors, oxidative stress, excitotoxicity, autoimmu-nity. and trauma. We suggest that the pathogenesis of idiopathic parkinsonism is likely to be multifactorial, deriving from environmental factor(s) acting upon a genetically predisposed individual. Because of the compelling evidence indicating common clinical and pathological findings in idiopathic parkinson-ism. Alzheimer’s disease, and amyotrophic lateral sclerosis, we believe that these conditions result from pathological processes with more similarity than diversity. A primary glutamatergic cell neocortical abnormality provides an attractive unifying explanation which may explain the overlapping abnormali-ties found in idiopathic parkinsonism. Alzheimer's disease, and amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)6-23
Number of pages18
JournalEuropean Neurology
Volume33
DOIs
StatePublished - Jan 1 1993

Keywords

  • Idiopathic parkinsonism
  • Parkinson’s disease
  • Pathogenesis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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