Pathogenesis of Diabetic Neuropathy

Albert I. Winegrad, David A. Simmons, Donald B. Martin, Anders A.f. Sima, Douglas A. Greene, Tom Bohr, Peter James Dyck, Bruce R. Zimmerman, Todd H. Vilen, Sharon R. Minnerath, Jeannine L. Karnes, Jeffrey K. Yao, Joseph F. Poduslo, Anders A.f. Sima, Douglas A. Greene

Research output: Contribution to journalLetterpeer-review

3 Scopus citations

Abstract

To the Editor: The study by Dyck et al. in the September 1 issue of the Journal 1 permits none of the conclusions presented concerning the roles of sorbitol or myo-inositol in the pathogenesis of diabetic neuropathy. Dyck et al. found higher levels of glucose, sorbitol, and fructose in specimens of sural nerve from 25 diabetics (84 percent with neuropathy) than in specimens from controls, which was predictable in view of the hyperglycemia of the diabetics. Peripheral-nerve levels of glucose, sorbitol, and fructose fluctuate with the plasma glucose level, and the potential rapidity and magnitude of these fluctuations in diabetics…

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalNew England Journal of Medicine
Volume320
Issue number1
DOIs
StatePublished - Jan 5 1989

ASJC Scopus subject areas

  • Medicine(all)

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