Pathogenesis of Diabetic Neuropathy

Albert I. Winegrad, David A. Simmons, Donald B. Martin, Anders A.f. Sima, Douglas A. Greene, Tom Bohr, Peter J Dyck, Bruce R. Zimmerman, Todd H. Vilen, Sharon R. Minnerath, Jeannine L. Karnes, Jeffrey K. Yao, Joseph F. Poduslo, Anders A.f. Sima, Douglas A. Greene

Research output: Contribution to journalLetter

3 Citations (Scopus)

Abstract

To the Editor: The study by Dyck et al. in the September 1 issue of the Journal 1 permits none of the conclusions presented concerning the roles of sorbitol or myo-inositol in the pathogenesis of diabetic neuropathy. Dyck et al. found higher levels of glucose, sorbitol, and fructose in specimens of sural nerve from 25 diabetics (84 percent with neuropathy) than in specimens from controls, which was predictable in view of the hyperglycemia of the diabetics. Peripheral-nerve levels of glucose, sorbitol, and fructose fluctuate with the plasma glucose level, and the potential rapidity and magnitude of these fluctuations in diabetics…

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalNew England Journal of Medicine
Volume320
Issue number1
DOIs
StatePublished - Jan 5 1989

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Sorbitol
Diabetic Neuropathies
Fructose
Glucose
Sural Nerve
Inositol
Peripheral Nerves
Hyperglycemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Winegrad, A. I., Simmons, D. A., Martin, D. B., Sima, A. A. F., Greene, D. A., Bohr, T., ... Greene, D. A. (1989). Pathogenesis of Diabetic Neuropathy. New England Journal of Medicine, 320(1), 57-60. https://doi.org/10.1056/NEJM198901053200112

Pathogenesis of Diabetic Neuropathy. / Winegrad, Albert I.; Simmons, David A.; Martin, Donald B.; Sima, Anders A.f.; Greene, Douglas A.; Bohr, Tom; Dyck, Peter J; Zimmerman, Bruce R.; Vilen, Todd H.; Minnerath, Sharon R.; Karnes, Jeannine L.; Yao, Jeffrey K.; Poduslo, Joseph F.; Sima, Anders A.f.; Greene, Douglas A.

In: New England Journal of Medicine, Vol. 320, No. 1, 05.01.1989, p. 57-60.

Research output: Contribution to journalLetter

Winegrad, AI, Simmons, DA, Martin, DB, Sima, AAF, Greene, DA, Bohr, T, Dyck, PJ, Zimmerman, BR, Vilen, TH, Minnerath, SR, Karnes, JL, Yao, JK, Poduslo, JF, Sima, AAF & Greene, DA 1989, 'Pathogenesis of Diabetic Neuropathy', New England Journal of Medicine, vol. 320, no. 1, pp. 57-60. https://doi.org/10.1056/NEJM198901053200112
Winegrad AI, Simmons DA, Martin DB, Sima AAF, Greene DA, Bohr T et al. Pathogenesis of Diabetic Neuropathy. New England Journal of Medicine. 1989 Jan 5;320(1):57-60. https://doi.org/10.1056/NEJM198901053200112
Winegrad, Albert I. ; Simmons, David A. ; Martin, Donald B. ; Sima, Anders A.f. ; Greene, Douglas A. ; Bohr, Tom ; Dyck, Peter J ; Zimmerman, Bruce R. ; Vilen, Todd H. ; Minnerath, Sharon R. ; Karnes, Jeannine L. ; Yao, Jeffrey K. ; Poduslo, Joseph F. ; Sima, Anders A.f. ; Greene, Douglas A. / Pathogenesis of Diabetic Neuropathy. In: New England Journal of Medicine. 1989 ; Vol. 320, No. 1. pp. 57-60.
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