Pathogenesis of Diabetic Neuropathy

Albert I. Winegrad; David A. Simmons; Donald B. Martin; Anders A.f. Sima; Douglas A. Greene; Tom Bohr; Peter James Dyck; Bruce R. Zimmerman; Todd H. Vilen; Sharon R. Minnerath; Jeannine L. Karnes; Jeffrey K. Yao; Joseph F. Poduslo; Anders A.f. Sima; Douglas A. Greene

doi:10.1056/NEJM198901053200112

Pathogenesis of Diabetic Neuropathy

Albert I. Winegrad, David A. Simmons, Donald B. Martin, Anders A.f. Sima, Douglas A. Greene, Tom Bohr, Peter James Dyck, Bruce R. Zimmerman, Todd H. Vilen, Sharon R. Minnerath, Jeannine L. Karnes, Jeffrey K. Yao, Joseph F. Poduslo, Anders A.f. Sima, Douglas A. Greene

Neurology

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

To the Editor: The study by Dyck et al. in the September 1 issue of the Journal ¹ permits none of the conclusions presented concerning the roles of sorbitol or myo-inositol in the pathogenesis of diabetic neuropathy. Dyck et al. found higher levels of glucose, sorbitol, and fructose in specimens of sural nerve from 25 diabetics (84 percent with neuropathy) than in specimens from controls, which was predictable in view of the hyperglycemia of the diabetics. Peripheral-nerve levels of glucose, sorbitol, and fructose fluctuate with the plasma glucose level, and the potential rapidity and magnitude of these fluctuations in diabetics…

Original language	English (US)
Pages (from-to)	57-60
Number of pages	4
Journal	New England Journal of Medicine
Volume	320
Issue number	1
DOIs	https://doi.org/10.1056/NEJM198901053200112
State	Published - Jan 5 1989

ASJC Scopus subject areas

General Medicine

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10.1056/NEJM198901053200112

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@article{7901e59f848944ba84668da93ef6014c,

title = "Pathogenesis of Diabetic Neuropathy",

abstract = "To the Editor: The study by Dyck et al. in the September 1 issue of the Journal 1 permits none of the conclusions presented concerning the roles of sorbitol or myo-inositol in the pathogenesis of diabetic neuropathy. Dyck et al. found higher levels of glucose, sorbitol, and fructose in specimens of sural nerve from 25 diabetics (84 percent with neuropathy) than in specimens from controls, which was predictable in view of the hyperglycemia of the diabetics. Peripheral-nerve levels of glucose, sorbitol, and fructose fluctuate with the plasma glucose level, and the potential rapidity and magnitude of these fluctuations in diabetics…",

author = "Winegrad, {Albert I.} and Simmons, {David A.} and Martin, {Donald B.} and Sima, {Anders A.f.} and Greene, {Douglas A.} and Tom Bohr and Dyck, {Peter James} and Zimmerman, {Bruce R.} and Vilen, {Todd H.} and Minnerath, {Sharon R.} and Karnes, {Jeannine L.} and Yao, {Jeffrey K.} and Poduslo, {Joseph F.} and Sima, {Anders A.f.} and Greene, {Douglas A.}",

year = "1989",

month = jan,

day = "5",

doi = "10.1056/NEJM198901053200112",

language = "English (US)",

volume = "320",

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journal = "New England Journal of Medicine",

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TY - JOUR

T1 - Pathogenesis of Diabetic Neuropathy

AU - Winegrad, Albert I.

AU - Simmons, David A.

AU - Martin, Donald B.

AU - Sima, Anders A.f.

AU - Greene, Douglas A.

AU - Bohr, Tom

AU - Dyck, Peter James

AU - Zimmerman, Bruce R.

AU - Vilen, Todd H.

AU - Minnerath, Sharon R.

AU - Karnes, Jeannine L.

AU - Yao, Jeffrey K.

AU - Poduslo, Joseph F.

AU - Sima, Anders A.f.

AU - Greene, Douglas A.

PY - 1989/1/5

Y1 - 1989/1/5

N2 - To the Editor: The study by Dyck et al. in the September 1 issue of the Journal 1 permits none of the conclusions presented concerning the roles of sorbitol or myo-inositol in the pathogenesis of diabetic neuropathy. Dyck et al. found higher levels of glucose, sorbitol, and fructose in specimens of sural nerve from 25 diabetics (84 percent with neuropathy) than in specimens from controls, which was predictable in view of the hyperglycemia of the diabetics. Peripheral-nerve levels of glucose, sorbitol, and fructose fluctuate with the plasma glucose level, and the potential rapidity and magnitude of these fluctuations in diabetics…

AB - To the Editor: The study by Dyck et al. in the September 1 issue of the Journal 1 permits none of the conclusions presented concerning the roles of sorbitol or myo-inositol in the pathogenesis of diabetic neuropathy. Dyck et al. found higher levels of glucose, sorbitol, and fructose in specimens of sural nerve from 25 diabetics (84 percent with neuropathy) than in specimens from controls, which was predictable in view of the hyperglycemia of the diabetics. Peripheral-nerve levels of glucose, sorbitol, and fructose fluctuate with the plasma glucose level, and the potential rapidity and magnitude of these fluctuations in diabetics…

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DO - 10.1056/NEJM198901053200112

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 1

ER -

Pathogenesis of Diabetic Neuropathy

Abstract

ASJC Scopus subject areas

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