Pathogenesis of Alcoholic Liver Disease

Winston Dunn, Vijay Shah

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Alcoholic liver disease includes a broad clinical-histological spectrum from simple steatosis, cirrhosis, acute alcoholic hepatitis with or without cirrhosis to hepatocellular carcinoma as a complication of cirrhosis. The pathogenesis of alcoholic liver disease can be conceptually divided into (1) ethanol-mediated liver injury, (2) inflammatory immune response to injury, (3) intestinal permeability and microbiome changes. Corticosteroids may improve outcomes, but this is controversial and probably only impacts short-term survival. New pathophysiology-based therapies are under study, including antibiotics, caspase inhibition, interleukin-22, anakinra, FXR agonist and others. These studies provide hope for better future outcomes for this difficult disease.

Original languageEnglish (US)
Pages (from-to)445-456
Number of pages12
JournalClinics in Liver Disease
Volume20
Issue number3
DOIs
StatePublished - Aug 1 2016

Fingerprint

Alcoholic Liver Diseases
Fibrosis
Interleukin 1 Receptor Antagonist Protein
Alcoholic Hepatitis
Wounds and Injuries
Caspases
Hepatocellular Carcinoma
Permeability
Adrenal Cortex Hormones
Ethanol
Anti-Bacterial Agents
Liver
Therapeutics

Keywords

  • Alcoholic hepatitis
  • Alcoholic liver disease
  • Corticosteroids
  • Intestinal permeability
  • Microbiome
  • Sterile necrosis

ASJC Scopus subject areas

  • Hepatology

Cite this

Pathogenesis of Alcoholic Liver Disease. / Dunn, Winston; Shah, Vijay.

In: Clinics in Liver Disease, Vol. 20, No. 3, 01.08.2016, p. 445-456.

Research output: Contribution to journalReview article

Dunn, Winston ; Shah, Vijay. / Pathogenesis of Alcoholic Liver Disease. In: Clinics in Liver Disease. 2016 ; Vol. 20, No. 3. pp. 445-456.
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