Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness: A retrospective cohort study

Mark S. Riddle, Joseph A Murray, Brooks D. Cash, Mark Pimentel, Chad K. Porter

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: The US CDC recently estimated over 2 million foodborne illnesses annually are caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp., and Yersinia enterocolitica. While recent data suggest functional gastrointestinal disorders are associated with these infections, studies linking foodborne illness to celiac disease (CD) are limited. We utilized a US Department of Defense medical encounter database to evaluate the risk of CD following select foodborne infections. Methods: We identified subjects with acute gastroenteritis between 1998 and 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp., or Y. enterocolitica and matched each with up to 4 unexposed subjects. Exposed and unexposed subjects were followed for incident CD diagnosis for their entire military record duration (or a minimum of 1 year). Relative risks were calculated using modified Poisson regression to determine the relationship between pathogen-attributable gastroenteritis and CD while controlling for covariates. Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738; Salmonella: 624; Shigella: 376; Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of CD was 0.05. We found a suggested risk of CD after Campylobacter, but not other foodborne infection etiologies. Conclusions: These data support a previous study demonstrating increased risk of CD following Campylobacteriosis and highlight the need for additional research into how infections might trigger CD in susceptible individuals.

Original languageEnglish (US)
Pages (from-to)3242-3245
Number of pages4
JournalDigestive Diseases and Sciences
Volume58
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Foodborne Diseases
Celiac Disease
Cohort Studies
Retrospective Studies
Campylobacter
Shigella
Gastroenteritis
Salmonella
Yersinia enterocolitica
Infection
United States Department of Defense
Yersinia
Gastrointestinal Diseases
Centers for Disease Control and Prevention (U.S.)
Databases
Incidence
Research

Keywords

  • Campylobacteriosis
  • Celiac disease
  • Cohort study
  • Epidemiology
  • Foodborne illness

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness : A retrospective cohort study. / Riddle, Mark S.; Murray, Joseph A; Cash, Brooks D.; Pimentel, Mark; Porter, Chad K.

In: Digestive Diseases and Sciences, Vol. 58, No. 11, 11.2013, p. 3242-3245.

Research output: Contribution to journalArticle

Riddle, Mark S. ; Murray, Joseph A ; Cash, Brooks D. ; Pimentel, Mark ; Porter, Chad K. / Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness : A retrospective cohort study. In: Digestive Diseases and Sciences. 2013 ; Vol. 58, No. 11. pp. 3242-3245.
@article{35dc6580c2e24ea0ae14dceec47c3ae8,
title = "Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness: A retrospective cohort study",
abstract = "Background: The US CDC recently estimated over 2 million foodborne illnesses annually are caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp., and Yersinia enterocolitica. While recent data suggest functional gastrointestinal disorders are associated with these infections, studies linking foodborne illness to celiac disease (CD) are limited. We utilized a US Department of Defense medical encounter database to evaluate the risk of CD following select foodborne infections. Methods: We identified subjects with acute gastroenteritis between 1998 and 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp., or Y. enterocolitica and matched each with up to 4 unexposed subjects. Exposed and unexposed subjects were followed for incident CD diagnosis for their entire military record duration (or a minimum of 1 year). Relative risks were calculated using modified Poisson regression to determine the relationship between pathogen-attributable gastroenteritis and CD while controlling for covariates. Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738; Salmonella: 624; Shigella: 376; Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of CD was 0.05. We found a suggested risk of CD after Campylobacter, but not other foodborne infection etiologies. Conclusions: These data support a previous study demonstrating increased risk of CD following Campylobacteriosis and highlight the need for additional research into how infections might trigger CD in susceptible individuals.",
keywords = "Campylobacteriosis, Celiac disease, Cohort study, Epidemiology, Foodborne illness",
author = "Riddle, {Mark S.} and Murray, {Joseph A} and Cash, {Brooks D.} and Mark Pimentel and Porter, {Chad K.}",
year = "2013",
month = "11",
doi = "10.1007/s10620-013-2733-7",
language = "English (US)",
volume = "58",
pages = "3242--3245",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "11",

}

TY - JOUR

T1 - Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness

T2 - A retrospective cohort study

AU - Riddle, Mark S.

AU - Murray, Joseph A

AU - Cash, Brooks D.

AU - Pimentel, Mark

AU - Porter, Chad K.

PY - 2013/11

Y1 - 2013/11

N2 - Background: The US CDC recently estimated over 2 million foodborne illnesses annually are caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp., and Yersinia enterocolitica. While recent data suggest functional gastrointestinal disorders are associated with these infections, studies linking foodborne illness to celiac disease (CD) are limited. We utilized a US Department of Defense medical encounter database to evaluate the risk of CD following select foodborne infections. Methods: We identified subjects with acute gastroenteritis between 1998 and 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp., or Y. enterocolitica and matched each with up to 4 unexposed subjects. Exposed and unexposed subjects were followed for incident CD diagnosis for their entire military record duration (or a minimum of 1 year). Relative risks were calculated using modified Poisson regression to determine the relationship between pathogen-attributable gastroenteritis and CD while controlling for covariates. Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738; Salmonella: 624; Shigella: 376; Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of CD was 0.05. We found a suggested risk of CD after Campylobacter, but not other foodborne infection etiologies. Conclusions: These data support a previous study demonstrating increased risk of CD following Campylobacteriosis and highlight the need for additional research into how infections might trigger CD in susceptible individuals.

AB - Background: The US CDC recently estimated over 2 million foodborne illnesses annually are caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp., and Yersinia enterocolitica. While recent data suggest functional gastrointestinal disorders are associated with these infections, studies linking foodborne illness to celiac disease (CD) are limited. We utilized a US Department of Defense medical encounter database to evaluate the risk of CD following select foodborne infections. Methods: We identified subjects with acute gastroenteritis between 1998 and 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp., or Y. enterocolitica and matched each with up to 4 unexposed subjects. Exposed and unexposed subjects were followed for incident CD diagnosis for their entire military record duration (or a minimum of 1 year). Relative risks were calculated using modified Poisson regression to determine the relationship between pathogen-attributable gastroenteritis and CD while controlling for covariates. Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738; Salmonella: 624; Shigella: 376; Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of CD was 0.05. We found a suggested risk of CD after Campylobacter, but not other foodborne infection etiologies. Conclusions: These data support a previous study demonstrating increased risk of CD following Campylobacteriosis and highlight the need for additional research into how infections might trigger CD in susceptible individuals.

KW - Campylobacteriosis

KW - Celiac disease

KW - Cohort study

KW - Epidemiology

KW - Foodborne illness

UR - http://www.scopus.com/inward/record.url?scp=84889596284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889596284&partnerID=8YFLogxK

U2 - 10.1007/s10620-013-2733-7

DO - 10.1007/s10620-013-2733-7

M3 - Article

C2 - 23812827

AN - SCOPUS:84889596284

VL - 58

SP - 3242

EP - 3245

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 11

ER -