TY - JOUR
T1 - Pathobiology of biliary epithelia
AU - Cheung, Angela C.
AU - Lorenzo Pisarello, Maria J.
AU - LaRusso, Nicholas F.
N1 - Publisher Copyright:
© 2017
PY - 2018/4
Y1 - 2018/4
N2 - Cholangiocytes are epithelial cells that line the intra- and extrahepatic biliary tree. They serve predominantly to mediate the content of luminal biliary fluid, which is controlled via numerous signaling pathways influenced by endogenous (e.g., bile acids, nucleotides, hormones, neurotransmitters) and exogenous (e.g., microbes/microbial products, drugs etc.) molecules. When injured, cholangiocytes undergo apoptosis/lysis, repair and proliferation. They also become senescent, a form of cell cycle arrest, which may prevent propagation of injury and/or malignant transformation. Senescent cholangiocytes can undergo further transformation to a senescence-associated secretory phenotype (SASP), where they begin secreting pro-inflammatory and pro-fibrotic signals that may contribute to disease initiation and progression. These and other concepts related to cholangiocyte pathobiology will be reviewed herein. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
AB - Cholangiocytes are epithelial cells that line the intra- and extrahepatic biliary tree. They serve predominantly to mediate the content of luminal biliary fluid, which is controlled via numerous signaling pathways influenced by endogenous (e.g., bile acids, nucleotides, hormones, neurotransmitters) and exogenous (e.g., microbes/microbial products, drugs etc.) molecules. When injured, cholangiocytes undergo apoptosis/lysis, repair and proliferation. They also become senescent, a form of cell cycle arrest, which may prevent propagation of injury and/or malignant transformation. Senescent cholangiocytes can undergo further transformation to a senescence-associated secretory phenotype (SASP), where they begin secreting pro-inflammatory and pro-fibrotic signals that may contribute to disease initiation and progression. These and other concepts related to cholangiocyte pathobiology will be reviewed herein. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
KW - Apoptosis
KW - Bile
KW - Cholangiocytes
KW - Cholangiopathies
KW - Proliferation
KW - Senescence
UR - http://www.scopus.com/inward/record.url?scp=85025470170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025470170&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2017.06.024
DO - 10.1016/j.bbadis.2017.06.024
M3 - Review article
C2 - 28716705
AN - SCOPUS:85025470170
SN - 0925-4439
VL - 1864
SP - 1220
EP - 1231
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 4
ER -