Pathobiology of biliary epithelia

S. K. Roberts, Nicholas F La Russo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Recently, principally owing to the development of suitable experimental models, significant advances have been made in our understanding of the biological and pathobiological importance of intrahepatic biliary epithelial cells, or cholangiocytes. These advances include 1) the development of techniques to isolate and culture rodent and human cholangiocytes; 2) an appreciation of the mechanisms by which cholangiocytes contribute to bile formation via hormone-stimulated secretion of ions and water; and 3) a recognition that cholangiocytes are candidate target cells in several important chronic liver diseases. In this review, we first discuss the experimental models recently developed to study biliary epithelia then detail current concepts on the cellular mechanisms of hormone-induced ductal bile secretion. We then briefly summarize selected information on the pathophysiology of bile duct injury, emphasizing those liver diseases in which cholangiocytes appear to be the principal targets for immune-mediated destruction.

Original languageEnglish (US)
Pages (from-to)526-533
Number of pages8
JournalCurrent Opinion in Gastroenterology
Volume10
Issue number5
StatePublished - 1994

Fingerprint

Bile
Liver Diseases
Theoretical Models
Epithelium
Hormones
Bile Ducts
Rodentia
Chronic Disease
Epithelial Cells
Ions
Water
Wounds and Injuries

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pathobiology of biliary epithelia. / Roberts, S. K.; La Russo, Nicholas F.

In: Current Opinion in Gastroenterology, Vol. 10, No. 5, 1994, p. 526-533.

Research output: Contribution to journalArticle

Roberts, S. K. ; La Russo, Nicholas F. / Pathobiology of biliary epithelia. In: Current Opinion in Gastroenterology. 1994 ; Vol. 10, No. 5. pp. 526-533.
@article{8840449f44fa4bfc9f92c4a4d23933c4,
title = "Pathobiology of biliary epithelia",
abstract = "Recently, principally owing to the development of suitable experimental models, significant advances have been made in our understanding of the biological and pathobiological importance of intrahepatic biliary epithelial cells, or cholangiocytes. These advances include 1) the development of techniques to isolate and culture rodent and human cholangiocytes; 2) an appreciation of the mechanisms by which cholangiocytes contribute to bile formation via hormone-stimulated secretion of ions and water; and 3) a recognition that cholangiocytes are candidate target cells in several important chronic liver diseases. In this review, we first discuss the experimental models recently developed to study biliary epithelia then detail current concepts on the cellular mechanisms of hormone-induced ductal bile secretion. We then briefly summarize selected information on the pathophysiology of bile duct injury, emphasizing those liver diseases in which cholangiocytes appear to be the principal targets for immune-mediated destruction.",
author = "Roberts, {S. K.} and {La Russo}, {Nicholas F}",
year = "1994",
language = "English (US)",
volume = "10",
pages = "526--533",
journal = "Current Opinion in Gastroenterology",
issn = "0267-1379",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Pathobiology of biliary epithelia

AU - Roberts, S. K.

AU - La Russo, Nicholas F

PY - 1994

Y1 - 1994

N2 - Recently, principally owing to the development of suitable experimental models, significant advances have been made in our understanding of the biological and pathobiological importance of intrahepatic biliary epithelial cells, or cholangiocytes. These advances include 1) the development of techniques to isolate and culture rodent and human cholangiocytes; 2) an appreciation of the mechanisms by which cholangiocytes contribute to bile formation via hormone-stimulated secretion of ions and water; and 3) a recognition that cholangiocytes are candidate target cells in several important chronic liver diseases. In this review, we first discuss the experimental models recently developed to study biliary epithelia then detail current concepts on the cellular mechanisms of hormone-induced ductal bile secretion. We then briefly summarize selected information on the pathophysiology of bile duct injury, emphasizing those liver diseases in which cholangiocytes appear to be the principal targets for immune-mediated destruction.

AB - Recently, principally owing to the development of suitable experimental models, significant advances have been made in our understanding of the biological and pathobiological importance of intrahepatic biliary epithelial cells, or cholangiocytes. These advances include 1) the development of techniques to isolate and culture rodent and human cholangiocytes; 2) an appreciation of the mechanisms by which cholangiocytes contribute to bile formation via hormone-stimulated secretion of ions and water; and 3) a recognition that cholangiocytes are candidate target cells in several important chronic liver diseases. In this review, we first discuss the experimental models recently developed to study biliary epithelia then detail current concepts on the cellular mechanisms of hormone-induced ductal bile secretion. We then briefly summarize selected information on the pathophysiology of bile duct injury, emphasizing those liver diseases in which cholangiocytes appear to be the principal targets for immune-mediated destruction.

UR - http://www.scopus.com/inward/record.url?scp=0028021876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028021876&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 526

EP - 533

JO - Current Opinion in Gastroenterology

JF - Current Opinion in Gastroenterology

SN - 0267-1379

IS - 5

ER -