Patent foramen ovale closure for secondary stroke prevention

Mohamad Alkhouli; Horst Sievert; David R. Holmes

doi:10.1093/eurheartj/ehz157

Patent foramen ovale closure for secondary stroke prevention

Mohamad Alkhouli, Horst Sievert, David R. Holmes

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Transcatheter closure of patent foramen ovale (PFO) in patients with cryptogenic stroke is gaining momentum after the recent publication of four randomized clinical trials suggesting its benefit. This article provides a contemporary overview of the anatomy and pathophysiology of PFO, the available diagnostic tools for the assessment and risk stratification of PFO, and the current and future landscape of PFO closure devices and their optimal utilization. It also summarizes the current data on PFO closure for stroke prevention, and discusses the remaining open issues in the field of PFO closure.

Original language	English (US)
Pages (from-to)	2339-2349
Number of pages	11
Journal	European heart journal
Volume	40
Issue number	28
DOIs	https://doi.org/10.1093/eurheartj/ehz157
State	Published - Jul 21 2019

Keywords

Cryptogenic stroke
Device closure
Patent foramen ovale
Stroke prevention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1093/eurheartj/ehz157

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title = "Patent foramen ovale closure for secondary stroke prevention",

abstract = "Transcatheter closure of patent foramen ovale (PFO) in patients with cryptogenic stroke is gaining momentum after the recent publication of four randomized clinical trials suggesting its benefit. This article provides a contemporary overview of the anatomy and pathophysiology of PFO, the available diagnostic tools for the assessment and risk stratification of PFO, and the current and future landscape of PFO closure devices and their optimal utilization. It also summarizes the current data on PFO closure for stroke prevention, and discusses the remaining open issues in the field of PFO closure.",

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AU - Alkhouli, Mohamad

AU - Sievert, Horst

AU - Holmes, David R.

PY - 2019/7/21

Y1 - 2019/7/21

N2 - Transcatheter closure of patent foramen ovale (PFO) in patients with cryptogenic stroke is gaining momentum after the recent publication of four randomized clinical trials suggesting its benefit. This article provides a contemporary overview of the anatomy and pathophysiology of PFO, the available diagnostic tools for the assessment and risk stratification of PFO, and the current and future landscape of PFO closure devices and their optimal utilization. It also summarizes the current data on PFO closure for stroke prevention, and discusses the remaining open issues in the field of PFO closure.

AB - Transcatheter closure of patent foramen ovale (PFO) in patients with cryptogenic stroke is gaining momentum after the recent publication of four randomized clinical trials suggesting its benefit. This article provides a contemporary overview of the anatomy and pathophysiology of PFO, the available diagnostic tools for the assessment and risk stratification of PFO, and the current and future landscape of PFO closure devices and their optimal utilization. It also summarizes the current data on PFO closure for stroke prevention, and discusses the remaining open issues in the field of PFO closure.

KW - Cryptogenic stroke

KW - Device closure

KW - Patent foramen ovale

KW - Stroke prevention

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JO - European heart journal

JF - European heart journal

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Patent foramen ovale closure for secondary stroke prevention

Abstract

Keywords

ASJC Scopus subject areas

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