Patent foramen ovale and migraine

Hans Christoph Diener, Tobias Kurth, David William Dodick

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalCurrent Pain and Headache Reports
Volume11
Issue number3
DOIs
StatePublished - Jun 2007

Fingerprint

Patent Foramen Ovale
Migraine Disorders
Observational Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patent foramen ovale and migraine. / Diener, Hans Christoph; Kurth, Tobias; Dodick, David William.

In: Current Pain and Headache Reports, Vol. 11, No. 3, 06.2007, p. 236-240.

Research output: Contribution to journalArticle

Diener, Hans Christoph ; Kurth, Tobias ; Dodick, David William. / Patent foramen ovale and migraine. In: Current Pain and Headache Reports. 2007 ; Vol. 11, No. 3. pp. 236-240.
@article{ee6c61d266b443178a7bdaa71f8725ec,
title = "Patent foramen ovale and migraine",
abstract = "Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.",
author = "Diener, {Hans Christoph} and Tobias Kurth and Dodick, {David William}",
year = "2007",
month = "6",
doi = "10.1007/s11916-007-0196-2",
language = "English (US)",
volume = "11",
pages = "236--240",
journal = "Current Pain and Headache Reports",
issn = "1531-3433",
publisher = "Current Science, Inc.",
number = "3",

}

TY - JOUR

T1 - Patent foramen ovale and migraine

AU - Diener, Hans Christoph

AU - Kurth, Tobias

AU - Dodick, David William

PY - 2007/6

Y1 - 2007/6

N2 - Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.

AB - Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.

UR - http://www.scopus.com/inward/record.url?scp=34249812977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249812977&partnerID=8YFLogxK

U2 - 10.1007/s11916-007-0196-2

DO - 10.1007/s11916-007-0196-2

M3 - Article

VL - 11

SP - 236

EP - 240

JO - Current Pain and Headache Reports

JF - Current Pain and Headache Reports

SN - 1531-3433

IS - 3

ER -