TY - JOUR
T1 - Patent foramen ovale and migraine
AU - Diener, Hans Christoph
AU - Kurth, Tobias
AU - Dodick, David
PY - 2007/6
Y1 - 2007/6
N2 - Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.
AB - Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.
UR - http://www.scopus.com/inward/record.url?scp=34249812977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249812977&partnerID=8YFLogxK
U2 - 10.1007/s11916-007-0196-2
DO - 10.1007/s11916-007-0196-2
M3 - Review article
C2 - 17504652
AN - SCOPUS:34249812977
SN - 1531-3433
VL - 11
SP - 236
EP - 240
JO - Current pain and headache reports
JF - Current pain and headache reports
IS - 3
ER -