Passive step response of airway smooth muscle

G. Ijpma, Ahmed M. Al-Jumaily, S. P. Cairns, Gary C Sieck

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The main driving mechanism in asthmatic attacks is the contraction of airway smooth muscle (ASM). Physiological loading of ASM by normal breathing and deep inspiration has been shown to reduce ASM contractile force. Our research aims to develop a mathematical model to describe the dynamic behavior of ASM. The current research focuses on a series of experiments on the step response of passive Airway smooth muscle tissues. The data showed results contradicting existing models on ASM dynamics. It is proposed that the results could be explained by multiple contractile elements embedded in a passive material matrix with multiplicative history and power law relaxation.

Original languageEnglish (US)
Title of host publicationIFMBE Proceedings
Pages594-596
Number of pages3
Volume25
Edition4
DOIs
StatePublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period9/7/099/12/09

Fingerprint

Step response
Muscle
Tissue
Mathematical models
Experiments

Keywords

  • Airway smooth muscle
  • Asthma
  • Power law relaxation
  • Step response

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Ijpma, G., Al-Jumaily, A. M., Cairns, S. P., & Sieck, G. C. (2009). Passive step response of airway smooth muscle. In IFMBE Proceedings (4 ed., Vol. 25, pp. 594-596) https://doi.org/10.1007/978-3-642-03882-2-157

Passive step response of airway smooth muscle. / Ijpma, G.; Al-Jumaily, Ahmed M.; Cairns, S. P.; Sieck, Gary C.

IFMBE Proceedings. Vol. 25 4. ed. 2009. p. 594-596.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ijpma, G, Al-Jumaily, AM, Cairns, SP & Sieck, GC 2009, Passive step response of airway smooth muscle. in IFMBE Proceedings. 4 edn, vol. 25, pp. 594-596, World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics, Munich, Germany, 9/7/09. https://doi.org/10.1007/978-3-642-03882-2-157
Ijpma G, Al-Jumaily AM, Cairns SP, Sieck GC. Passive step response of airway smooth muscle. In IFMBE Proceedings. 4 ed. Vol. 25. 2009. p. 594-596 https://doi.org/10.1007/978-3-642-03882-2-157
Ijpma, G. ; Al-Jumaily, Ahmed M. ; Cairns, S. P. ; Sieck, Gary C. / Passive step response of airway smooth muscle. IFMBE Proceedings. Vol. 25 4. ed. 2009. pp. 594-596
@inproceedings{7f9a7b30f00b4d86b9fb81adac72e35b,
title = "Passive step response of airway smooth muscle",
abstract = "The main driving mechanism in asthmatic attacks is the contraction of airway smooth muscle (ASM). Physiological loading of ASM by normal breathing and deep inspiration has been shown to reduce ASM contractile force. Our research aims to develop a mathematical model to describe the dynamic behavior of ASM. The current research focuses on a series of experiments on the step response of passive Airway smooth muscle tissues. The data showed results contradicting existing models on ASM dynamics. It is proposed that the results could be explained by multiple contractile elements embedded in a passive material matrix with multiplicative history and power law relaxation.",
keywords = "Airway smooth muscle, Asthma, Power law relaxation, Step response",
author = "G. Ijpma and Al-Jumaily, {Ahmed M.} and Cairns, {S. P.} and Sieck, {Gary C}",
year = "2009",
doi = "10.1007/978-3-642-03882-2-157",
language = "English (US)",
isbn = "9783642038815",
volume = "25",
pages = "594--596",
booktitle = "IFMBE Proceedings",
edition = "4",

}

TY - GEN

T1 - Passive step response of airway smooth muscle

AU - Ijpma, G.

AU - Al-Jumaily, Ahmed M.

AU - Cairns, S. P.

AU - Sieck, Gary C

PY - 2009

Y1 - 2009

N2 - The main driving mechanism in asthmatic attacks is the contraction of airway smooth muscle (ASM). Physiological loading of ASM by normal breathing and deep inspiration has been shown to reduce ASM contractile force. Our research aims to develop a mathematical model to describe the dynamic behavior of ASM. The current research focuses on a series of experiments on the step response of passive Airway smooth muscle tissues. The data showed results contradicting existing models on ASM dynamics. It is proposed that the results could be explained by multiple contractile elements embedded in a passive material matrix with multiplicative history and power law relaxation.

AB - The main driving mechanism in asthmatic attacks is the contraction of airway smooth muscle (ASM). Physiological loading of ASM by normal breathing and deep inspiration has been shown to reduce ASM contractile force. Our research aims to develop a mathematical model to describe the dynamic behavior of ASM. The current research focuses on a series of experiments on the step response of passive Airway smooth muscle tissues. The data showed results contradicting existing models on ASM dynamics. It is proposed that the results could be explained by multiple contractile elements embedded in a passive material matrix with multiplicative history and power law relaxation.

KW - Airway smooth muscle

KW - Asthma

KW - Power law relaxation

KW - Step response

UR - http://www.scopus.com/inward/record.url?scp=77950143047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950143047&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-03882-2-157

DO - 10.1007/978-3-642-03882-2-157

M3 - Conference contribution

SN - 9783642038815

VL - 25

SP - 594

EP - 596

BT - IFMBE Proceedings

ER -