Passive step response of airway smooth muscle

G. Ijpma, Ahmed M. Al-Jumaily, S. P. Cairns, G. C. Sieck

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The main driving mechanism in asthmatic attacks is the contraction of airway smooth muscle (ASM). Physiological loading of ASM by normal breathing and deep inspiration has been shown to reduce ASM contractile force. Our research aims to develop a mathematical model to describe the dynamic behavior of ASM. The current research focuses on a series of experiments on the step response of passive Airway smooth muscle tissues. The data showed results contradicting existing models on ASM dynamics. It is proposed that the results could be explained by multiple contractile elements embedded in a passive material matrix with multiplicative history and power law relaxation.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
Pages594-596
Number of pages3
Edition4
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number4
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period9/7/099/12/09

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Keywords

  • Airway smooth muscle
  • Asthma
  • Power law relaxation
  • Step response

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Ijpma, G., Al-Jumaily, A. M., Cairns, S. P., & Sieck, G. C. (2009). Passive step response of airway smooth muscle. In World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics (4 ed., pp. 594-596). (IFMBE Proceedings; Vol. 25, No. 4). https://doi.org/10.1007/978-3-642-03882-2-157