Parvovirus vectors: Use and optimisation in cancer gene therapy

Boris Blechacz, Stephen J. Russell

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

With the increasing incidence and mortality of cancer worldwide, there is an urgent need for new therapeutic approaches. Gene therapy is one such approach and preliminary data are promising. Viral and nonviral vector systems for gene delivery are available, but most of the current systems suffer from disadvantages such as low transfection efficiencies, in vivo instability, targeting problems, mutagenic potential and immunogenicity. Viruses of the Parvoviridae family, which are characterised by their oncotropism, oncosuppression, long-term gene expression and human apathogenicity, potentially offer advantages as viral vectors. This article evaluates their usefulness in gene therapy strategies for cancer.

Original languageEnglish (US)
JournalExpert Reviews in Molecular Medicine
Volume6
Issue number16
DOIs
StatePublished - Jul 1 2004

Keywords

  • AAV
  • ARP
  • Cancer gene therapy
  • Parvovirus
  • Viral vector

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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