TY - JOUR
T1 - Parvovirus infection mimicking systemiclupus erythematosus
AU - Nesher, Gideon
AU - Osborn, Thomas G.
AU - Moore, Terry L.
N1 - Funding Information:
From the Division of Rheumatology, Department of Internal Medicine, Saint Louis University Health Sciences Center. Gideon Nesher, MD: Assistant Professor of Internal Medicine, Saint Louis University Health Sciences Center, Thomas G. Osborn, MD: Associate Professor of Internal Medicine, Saint Louis University Health Sciences Center," Terry L. Moore, MD: Professor of Internal Medicine and Pediatrics, Director, Division of Rheumatology, Saint Louis University Health Sciences Center. Supported in part by a grant from the State of Missouri for Regional Arthritis Centers. Address reprint requests to Gideon Nesher, MD, Assistant Professor of Internal Medicine, Saint Louis University Health Sciences Center, Division of Rheumatology, 1402 S Grand Blvd, R213 Doisy Hall, Saint Louis, MO 63104. Copyright © 1995 by W.B. Saunders Company 0049-0177/95/2405-000155. 00/0
PY - 1995/4
Y1 - 1995/4
N2 - There are striking similarities between human parvovirus B19 (HPV-B19)infection and systemic lupus erythematosus (SLE): both may present with malar rash, fever, arthropathy, myalgia, cytopenia, hypocomplementemia, anti-DNA, and antinuclear antibodies (ANA). Therefore, it is difficult at times to differentiate HPV-B19 infection from SLE presentation or exacerbation. We report 4 cases of HPV-B19 infection mimicking SLE and review 10 other reported cases, all of whom were women. The similarity to a typical SLE presentation was indeed striking: most patients presented with rash, arthropathy, myalgia, fever, and positive ANA. In some cases, HPV-1319 infection seemed to exacerbate SLE rather then resemble it, and differentiation was difficult. Nearly all patients improved within several weeks. However, a few patients had symptoms and laboratory abnormalities lasting more than 6 months. The possibility of HPV-B19 infection should be entertained in patients presenting with SLE-like features.
AB - There are striking similarities between human parvovirus B19 (HPV-B19)infection and systemic lupus erythematosus (SLE): both may present with malar rash, fever, arthropathy, myalgia, cytopenia, hypocomplementemia, anti-DNA, and antinuclear antibodies (ANA). Therefore, it is difficult at times to differentiate HPV-B19 infection from SLE presentation or exacerbation. We report 4 cases of HPV-B19 infection mimicking SLE and review 10 other reported cases, all of whom were women. The similarity to a typical SLE presentation was indeed striking: most patients presented with rash, arthropathy, myalgia, fever, and positive ANA. In some cases, HPV-1319 infection seemed to exacerbate SLE rather then resemble it, and differentiation was difficult. Nearly all patients improved within several weeks. However, a few patients had symptoms and laboratory abnormalities lasting more than 6 months. The possibility of HPV-B19 infection should be entertained in patients presenting with SLE-like features.
KW - autoantibodies
KW - parvovirus
KW - systemic lupus erythematosus
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U2 - 10.1016/S0049-0172(95)80001-8
DO - 10.1016/S0049-0172(95)80001-8
M3 - Article
C2 - 7604297
AN - SCOPUS:0028951601
SN - 0049-0172
VL - 24
SP - 297
EP - 303
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 5
ER -