PARP inhibition: PARP1 and beyond

Michèle Rouleau, Anand Patel, Michael J. Hendzel, Scott H. Kaufmann, Guy G. Poirier

Research output: Contribution to journalComment/debate

854 Scopus citations

Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalNature Reviews Cancer
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2010

    Fingerprint

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H., & Poirier, G. G. (2010). PARP inhibition: PARP1 and beyond. Nature Reviews Cancer, 10(4), 293-301. https://doi.org/10.1038/nrc2812