PARP inhibition: PARP1 and beyond

Michèle Rouleau, Anand Patel, Michael J. Hendzel, Scott H. Kaufmann, Guy G. Poirier

Research output: Contribution to journalComment/debatepeer-review

927 Scopus citations

Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalNature Reviews Cancer
Volume10
Issue number4
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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