PARP inhibition: PARP1 and beyond

Michèle Rouleau; Anand Patel; Michael J. Hendzel; Scott H. Kaufmann; Guy G. Poirier

doi:10.1038/nrc2812

PARP inhibition: PARP1 and beyond

Michèle Rouleau, Anand Patel, Michael J. Hendzel, Scott H. Kaufmann, Guy G. Poirier

Oncology

Research output: Contribution to journal › Comment/debate › peer-review

948 Scopus citations

Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

Original language	English (US)
Pages (from-to)	293-301
Number of pages	9
Journal	Nature Reviews Cancer
Volume	10
Issue number	4
DOIs	https://doi.org/10.1038/nrc2812
State	Published - Apr 2010

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc2812

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title = "PARP inhibition: PARP1 and beyond",

abstract = "Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.",

author = "Mich{\`e}le Rouleau and Anand Patel and Hendzel, {Michael J.} and Kaufmann, {Scott H.} and Poirier, {Guy G.}",

note = "Funding Information: The authors are supported by research funds from a Canada research chair in proteomics, the Canadian Institutes of Health Research (CIHR grants MOP-74648 and IG1-14052), the Cancer Research Society, the Alberta Cancer Board and the National Institutes of Health (NIH grant P50 CA136393-01).",

year = "2010",

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AU - Rouleau, Michèle

AU - Patel, Anand

AU - Hendzel, Michael J.

AU - Kaufmann, Scott H.

AU - Poirier, Guy G.

N1 - Funding Information: The authors are supported by research funds from a Canada research chair in proteomics, the Canadian Institutes of Health Research (CIHR grants MOP-74648 and IG1-14052), the Cancer Research Society, the Alberta Cancer Board and the National Institutes of Health (NIH grant P50 CA136393-01).

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N2 - Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

AB - Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

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PARP inhibition: PARP1 and beyond

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ASJC Scopus subject areas

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