Parkinson's disease, smoking, and family history

Alexis Elbaz, José Maria Manubens-Bertran, Marzia Baldereschi, Monique M B Breteler, Francesco Grigoletto, Secundino Lopez-Pousa, Jean François Dartigues, Annik Alpérovitch, Walter A Rocca, Christophe Tzourio

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age(±2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and ever-smoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95 % CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95 % CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalJournal of Neurology
Volume247
Issue number10
DOIs
StatePublished - 2000

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Parkinson Disease
Smoking
Case-Control Studies
Joints
Population
Age Groups
History
Interviews

Keywords

  • Case-control
  • Interaction
  • Parkinson's disease Family history
  • Smoking

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Elbaz, A., Manubens-Bertran, J. M., Baldereschi, M., Breteler, M. M. B., Grigoletto, F., Lopez-Pousa, S., ... Tzourio, C. (2000). Parkinson's disease, smoking, and family history. Journal of Neurology, 247(10), 793-798. https://doi.org/10.1007/s004150070095

Parkinson's disease, smoking, and family history. / Elbaz, Alexis; Manubens-Bertran, José Maria; Baldereschi, Marzia; Breteler, Monique M B; Grigoletto, Francesco; Lopez-Pousa, Secundino; Dartigues, Jean François; Alpérovitch, Annik; Rocca, Walter A; Tzourio, Christophe.

In: Journal of Neurology, Vol. 247, No. 10, 2000, p. 793-798.

Research output: Contribution to journalArticle

Elbaz, A, Manubens-Bertran, JM, Baldereschi, M, Breteler, MMB, Grigoletto, F, Lopez-Pousa, S, Dartigues, JF, Alpérovitch, A, Rocca, WA & Tzourio, C 2000, 'Parkinson's disease, smoking, and family history', Journal of Neurology, vol. 247, no. 10, pp. 793-798. https://doi.org/10.1007/s004150070095
Elbaz A, Manubens-Bertran JM, Baldereschi M, Breteler MMB, Grigoletto F, Lopez-Pousa S et al. Parkinson's disease, smoking, and family history. Journal of Neurology. 2000;247(10):793-798. https://doi.org/10.1007/s004150070095
Elbaz, Alexis ; Manubens-Bertran, José Maria ; Baldereschi, Marzia ; Breteler, Monique M B ; Grigoletto, Francesco ; Lopez-Pousa, Secundino ; Dartigues, Jean François ; Alpérovitch, Annik ; Rocca, Walter A ; Tzourio, Christophe. / Parkinson's disease, smoking, and family history. In: Journal of Neurology. 2000 ; Vol. 247, No. 10. pp. 793-798.
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