Parkinson's disease - Molecular mechanisms of disease

Jason L. Eriksen, Leonard Petrucelli

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

It has long been recognized that exposure to environmental influences can increase the risk for developing idiopathic Parkinson's disease. The recent characterization of several novel gene mutations in mitochonchondrial and protein handling pathways has shed new light on the underlying cellular disturbances involved in familial Parkinson's disease. These findings point to cellular targets for drug development in Parkinson's disease; however, more studies are needed to identify potential biomarkers that can be used in clinical studies.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalDrug Discovery Today: Disease Mechanisms
Volume1
Issue number4
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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