Parkinson's disease - Molecular mechanisms of disease

Jason L. Eriksen, Leonard Petrucelli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It has long been recognized that exposure to environmental influences can increase the risk for developing idiopathic Parkinson's disease. The recent characterization of several novel gene mutations in mitochonchondrial and protein handling pathways has shed new light on the underlying cellular disturbances involved in familial Parkinson's disease. These findings point to cellular targets for drug development in Parkinson's disease; however, more studies are needed to identify potential biomarkers that can be used in clinical studies.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalDrug Discovery Today: Disease Mechanisms
Volume1
Issue number4
DOIs
StatePublished - Dec 2004

Fingerprint

Parkinson Disease
Environmental Exposure
Biomarkers
Mutation
Pharmaceutical Preparations
Genes
Proteins
Clinical Studies

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Parkinson's disease - Molecular mechanisms of disease. / Eriksen, Jason L.; Petrucelli, Leonard.

In: Drug Discovery Today: Disease Mechanisms, Vol. 1, No. 4, 12.2004, p. 399-405.

Research output: Contribution to journalArticle

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