Parkinson's disease - Molecular mechanisms of disease

Jason L. Eriksen; Leonard Petrucelli

doi:10.1016/j.ddmec.2004.11.016

Parkinson's disease - Molecular mechanisms of disease

Jason L. Eriksen, Leonard Petrucelli

Neuroscience

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

It has long been recognized that exposure to environmental influences can increase the risk for developing idiopathic Parkinson's disease. The recent characterization of several novel gene mutations in mitochonchondrial and protein handling pathways has shed new light on the underlying cellular disturbances involved in familial Parkinson's disease. These findings point to cellular targets for drug development in Parkinson's disease; however, more studies are needed to identify potential biomarkers that can be used in clinical studies.

Original language	English (US)
Pages (from-to)	399-405
Number of pages	7
Journal	Drug Discovery Today: Disease Mechanisms
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmec.2004.11.016
State	Published - Dec 2004

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1016/j.ddmec.2004.11.016

Cite this

@article{03928a9282a6449fb2d4c94281fcbafd,

title = "Parkinson's disease - Molecular mechanisms of disease",

abstract = "It has long been recognized that exposure to environmental influences can increase the risk for developing idiopathic Parkinson's disease. The recent characterization of several novel gene mutations in mitochonchondrial and protein handling pathways has shed new light on the underlying cellular disturbances involved in familial Parkinson's disease. These findings point to cellular targets for drug development in Parkinson's disease; however, more studies are needed to identify potential biomarkers that can be used in clinical studies.",

author = "Eriksen, {Jason L.} and Leonard Petrucelli",

note = "Funding Information: L.P was supported by NIH grant NS41486 and Michael J. Fox grant 2A3137. J.E. was supported by a grant from the National Parkinson Foundation. ",

year = "2004",

month = dec,

doi = "10.1016/j.ddmec.2004.11.016",

language = "English (US)",

volume = "1",

pages = "399--405",

journal = "Drug Discovery Today: Disease Mechanisms",

issn = "1740-6765",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Parkinson's disease - Molecular mechanisms of disease

AU - Eriksen, Jason L.

AU - Petrucelli, Leonard

N1 - Funding Information: L.P was supported by NIH grant NS41486 and Michael J. Fox grant 2A3137. J.E. was supported by a grant from the National Parkinson Foundation.

PY - 2004/12

Y1 - 2004/12

N2 - It has long been recognized that exposure to environmental influences can increase the risk for developing idiopathic Parkinson's disease. The recent characterization of several novel gene mutations in mitochonchondrial and protein handling pathways has shed new light on the underlying cellular disturbances involved in familial Parkinson's disease. These findings point to cellular targets for drug development in Parkinson's disease; however, more studies are needed to identify potential biomarkers that can be used in clinical studies.

AB - It has long been recognized that exposure to environmental influences can increase the risk for developing idiopathic Parkinson's disease. The recent characterization of several novel gene mutations in mitochonchondrial and protein handling pathways has shed new light on the underlying cellular disturbances involved in familial Parkinson's disease. These findings point to cellular targets for drug development in Parkinson's disease; however, more studies are needed to identify potential biomarkers that can be used in clinical studies.

UR - http://www.scopus.com/inward/record.url?scp=23744480404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744480404&partnerID=8YFLogxK

U2 - 10.1016/j.ddmec.2004.11.016

DO - 10.1016/j.ddmec.2004.11.016

M3 - Review article

AN - SCOPUS:23744480404

SN - 1740-6765

VL - 1

SP - 399

EP - 405

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 4

ER -

Parkinson's disease - Molecular mechanisms of disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this