Parkinson's disease, cortical dysfunction, and alpha-synuclein

John N. Caviness, Lih Fen Lue, Thomas G. Beach, Joseph G. Hentz, Charles H. Adler, Lucia Sue, Ramin Sadeghi, Erika Driver-Dunckley, Virgilio G. Evidente, Marwan N. Sabbagh, Holly A. Shill, Douglas G. Walker

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The ability to understand how Parkinson's disease neurodegeneration leads to cortical dysfunction will be critical for developing therapeutic advances in Parkinson's disease dementia. The overall purpose of this project was to study the small-amplitude cortical myoclonus in Parkinson's disease as an in vivo model of focal cortical dysfunction secondary to Parkinson's disease neurodegeneration. The objectives were to test the hypothesis that cortical myoclonus in Parkinson's disease is linked to abnormal levels of α-synuclein in the primary motor cortex and to define its relationship to various biochemical, clinical, and pathological measures. The primary motor cortex was evaluated for 11 Parkinson's disease subjects with and 8 without electrophysiologically confirmed cortical myoclonus (the Parkinson's disease + myoclonus group and the Parkinson's disease group, respectively) who had premortem movement and cognitive testing. Similarly assessed 9 controls were used for comparison. Measurements for α-synuclein, Aβ-42 peptide, and other biochemical measures were made in the primary motor cortex. A 36% increase in α-synuclein was found in the motor cortex of Parkinson's disease + myoclonus cases when compared with Parkinson's disease without myoclonus. This occurred without significant differences in insoluble α-synuclein, phosphorylated to total α-synuclein ratio, or Aβ-42 peptide levels. Higher total motor cortex α-synuclein levels significantly correlated with the presence of cortical myoclonus but did not correlate with multiple clinical or pathological findings. These results suggest an association between elevated α-synuclein and the dysfunctional physiology arising from the motor cortex in Parkinson's disease + myoclonus cases. Alzheimer's disease pathology was not associated with cortical myoclonus in Parkinson's disease. Cortical myoclonus arising from the motor cortex is a model to study cortical dysfunction in Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)1436-1442
Number of pages7
JournalMovement Disorders
Volume26
Issue number8
DOIs
StatePublished - Jul 2011

Keywords

  • Alpha-synuclein
  • Cortex
  • Dementia
  • Myoclonus
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Caviness, J. N., Lue, L. F., Beach, T. G., Hentz, J. G., Adler, C. H., Sue, L., Sadeghi, R., Driver-Dunckley, E., Evidente, V. G., Sabbagh, M. N., Shill, H. A., & Walker, D. G. (2011). Parkinson's disease, cortical dysfunction, and alpha-synuclein. Movement Disorders, 26(8), 1436-1442. https://doi.org/10.1002/mds.23697