Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

Elena M. Cornejo Castro, Jens Waak, Stephanie S. Weber, Fabienne C. Fiesel, Philipp Oberhettinger, Monika Schütz, Ingo B. Autenrieth, Wolfdieter Springer, Philipp J. Kahle

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 -/- worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.

Original languageEnglish (US)
Pages (from-to)599-604
Number of pages6
JournalJournal of Neural Transmission
Volume117
Issue number5
DOIs
StatePublished - May 2010

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Keywords

  • Caenorhabditis elegans
  • DJ-1
  • Innate immunity
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F. C., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W., & Kahle, P. J. (2010). Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. Journal of Neural Transmission, 117(5), 599-604. https://doi.org/10.1007/s00702-010-0397-4