Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

Elena M. Cornejo Castro, Jens Waak, Stephanie S. Weber, Fabienne Fiesel, Philipp Oberhettinger, Monika Schütz, Ingo B. Autenrieth, Wolfdieter Springer, Philipp J. Kahle

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 -/- worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.

Original languageEnglish (US)
Pages (from-to)599-604
Number of pages6
JournalJournal of Neural Transmission
Volume117
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Caenorhabditis elegans
Innate Immunity
Parkinson Disease
p38 Mitogen-Activated Protein Kinases
Gram-Negative Bacteria
Astrocytes
Genes
Phosphorylation
Neurons
Brain

Keywords

  • Caenorhabditis elegans
  • DJ-1
  • Innate immunity
  • P38 pathway
  • Parkinson's disease

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F., Oberhettinger, P., Schütz, M., ... Kahle, P. J. (2010). Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. Journal of Neural Transmission, 117(5), 599-604. https://doi.org/10.1007/s00702-010-0397-4

Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. / Cornejo Castro, Elena M.; Waak, Jens; Weber, Stephanie S.; Fiesel, Fabienne; Oberhettinger, Philipp; Schütz, Monika; Autenrieth, Ingo B.; Springer, Wolfdieter; Kahle, Philipp J.

In: Journal of Neural Transmission, Vol. 117, No. 5, 05.2010, p. 599-604.

Research output: Contribution to journalArticle

Cornejo Castro, EM, Waak, J, Weber, SS, Fiesel, F, Oberhettinger, P, Schütz, M, Autenrieth, IB, Springer, W & Kahle, PJ 2010, 'Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans', Journal of Neural Transmission, vol. 117, no. 5, pp. 599-604. https://doi.org/10.1007/s00702-010-0397-4
Cornejo Castro, Elena M. ; Waak, Jens ; Weber, Stephanie S. ; Fiesel, Fabienne ; Oberhettinger, Philipp ; Schütz, Monika ; Autenrieth, Ingo B. ; Springer, Wolfdieter ; Kahle, Philipp J. / Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. In: Journal of Neural Transmission. 2010 ; Vol. 117, No. 5. pp. 599-604.
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