Abstract
DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 -/- worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.
Original language | English (US) |
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Pages (from-to) | 599-604 |
Number of pages | 6 |
Journal | Journal of Neural Transmission |
Volume | 117 |
Issue number | 5 |
DOIs | |
State | Published - May 2010 |
Keywords
- Caenorhabditis elegans
- DJ-1
- Innate immunity
- Parkinson's disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry