Parkinsonism, Lrrk2 G2019S, and tau neuropathology

A. Rajput; D. W. Dickson; C. A. Robinson; O. A. Ross; J. C. Dächsel; S. J. Lincoln; S. A. Cobb; M. L. Rajput; M. J. Farrer

doi:10.1212/01.wnl.0000240220.33950.0c

Parkinsonism, Lrrk2 G2019S, and tau neuropathology

A. Rajput, D. W. Dickson, C. A. Robinson, O. A. Ross, J. C. Dächsel, S. J. Lincoln, S. A. Cobb, M. L. Rajput, M. J. Farrer

Neuroscience

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157 Scopus citations

Abstract

Lrrk2 G2019S is predominantly associated with α-synuclein- immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus α-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or α-synuclein protein with Lrrk2.

Original language	English (US)
Pages (from-to)	1506-1508
Number of pages	3
Journal	Neurology
Volume	67
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000240220.33950.0c
State	Published - Oct 2006

ASJC Scopus subject areas

Clinical Neurology

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title = "Parkinsonism, Lrrk2 G2019S, and tau neuropathology",

abstract = "Lrrk2 G2019S is predominantly associated with α-synuclein- immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus α-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or α-synuclein protein with Lrrk2.",

author = "A. Rajput and Dickson, {D. W.} and Robinson, {C. A.} and Ross, {O. A.} and D{\"a}chsel, {J. C.} and Lincoln, {S. J.} and Cobb, {S. A.} and Rajput, {M. L.} and Farrer, {M. J.}",

year = "2006",

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doi = "10.1212/01.wnl.0000240220.33950.0c",

language = "English (US)",

volume = "67",

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TY - JOUR

T1 - Parkinsonism, Lrrk2 G2019S, and tau neuropathology

AU - Rajput, A.

AU - Dickson, D. W.

AU - Robinson, C. A.

AU - Ross, O. A.

AU - Dächsel, J. C.

AU - Lincoln, S. J.

AU - Cobb, S. A.

AU - Rajput, M. L.

AU - Farrer, M. J.

PY - 2006/10

Y1 - 2006/10

N2 - Lrrk2 G2019S is predominantly associated with α-synuclein- immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus α-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or α-synuclein protein with Lrrk2.

AB - Lrrk2 G2019S is predominantly associated with α-synuclein- immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus α-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or α-synuclein protein with Lrrk2.

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JO - Neurology

JF - Neurology

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Parkinsonism, Lrrk2 G2019S, and tau neuropathology

Abstract

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