Parkinsonism, Lrrk2 G2019S, and tau neuropathology

A. Rajput, D. W. Dickson, C. A. Robinson, O. A. Ross, J. C. Dächsel, S. J. Lincoln, S. A. Cobb, M. L. Rajput, M. J. Farrer

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154 Scopus citations

Abstract

Lrrk2 G2019S is predominantly associated with α-synuclein- immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus α-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or α-synuclein protein with Lrrk2.

Original languageEnglish (US)
Pages (from-to)1506-1508
Number of pages3
JournalNeurology
Volume67
Issue number8
DOIs
StatePublished - Oct 1 2006

ASJC Scopus subject areas

  • Clinical Neurology

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    Rajput, A., Dickson, D. W., Robinson, C. A., Ross, O. A., Dächsel, J. C., Lincoln, S. J., Cobb, S. A., Rajput, M. L., & Farrer, M. J. (2006). Parkinsonism, Lrrk2 G2019S, and tau neuropathology. Neurology, 67(8), 1506-1508. https://doi.org/10.1212/01.wnl.0000240220.33950.0c