Parkinsonism induced by solvent abuse

Ryan J. Uitti; Barry J. Snow; Hitoshi Shinotoh; Francois J.G. Vingerhoets; Margo Hayward; Stanley Hashimoto; John Richmond; Sanford P. Markey; Carol J. Markey; Donald B. Calne

doi:10.1002/ana.410350516

Parkinsonism induced by solvent abuse

Ryan J. Uitti, Barry J. Snow, Hitoshi Shinotoh, Francois J.G. Vingerhoets, Margo Hayward, Stanley Hashimoto, John Richmond, Sanford P. Markey, Carol J. Markey, Donald B. Calne

Neurology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits wee indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.

Original language	English (US)
Pages (from-to)	616-619
Number of pages	4
Journal	Annals of neurology
Volume	35
Issue number	5
DOIs	https://doi.org/10.1002/ana.410350516
State	Published - May 1994

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Parkinsonism induced by solvent abuse",

abstract = "We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits wee indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.",

author = "Uitti, {Ryan J.} and Snow, {Barry J.} and Hitoshi Shinotoh and Vingerhoets, {Francois J.G.} and Margo Hayward and Stanley Hashimoto and John Richmond and Markey, {Sanford P.} and Markey, {Carol J.} and Calne, {Donald B.}",

year = "1994",

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AU - Uitti, Ryan J.

AU - Snow, Barry J.

AU - Shinotoh, Hitoshi

AU - Vingerhoets, Francois J.G.

AU - Hayward, Margo

AU - Hashimoto, Stanley

AU - Richmond, John

AU - Markey, Sanford P.

AU - Markey, Carol J.

AU - Calne, Donald B.

PY - 1994/5

Y1 - 1994/5

N2 - We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits wee indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.

AB - We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits wee indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.

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JO - Annals of neurology

JF - Annals of neurology

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Parkinsonism induced by solvent abuse

Abstract

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