TY - GEN
T1 - Parathyroid hormone regulates histone deacetylases in osteoblasts
AU - Shimizu, Emi
AU - Selvamurugan, Nagarajan
AU - Westendorf, Jennifer J.
AU - Partridge, Nicola C.
PY - 2007/11
Y1 - 2007/11
N2 - Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription. Understanding the mechanism of how HDACs affect osteoblast differentiation and mineralization will identify new theraupeutic methods for bone diseases, such as osteoporosis and multiple myeloma.
AB - Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription. Understanding the mechanism of how HDACs affect osteoblast differentiation and mineralization will identify new theraupeutic methods for bone diseases, such as osteoporosis and multiple myeloma.
KW - Histone deacetylases
KW - Osteoblasts
KW - Parathyroid hormone
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U2 - 10.1196/annals.1402.037
DO - 10.1196/annals.1402.037
M3 - Conference contribution
C2 - 17656568
AN - SCOPUS:37249016934
SN - 9781573316842
T3 - Annals of the New York Academy of Sciences
SP - 349
EP - 353
BT - Skeletal Biology and Medicine, Part A
PB - Blackwell Publishing Inc.
ER -