Paraoxonase gene mutations in amyotrophic lateral sclerosis

Nicola Ticozzi; Ashley Lyn LeClerc; Pamela J. Keagle; Jonathan D. Glass; Anne Marie Wills; Marka Van Blitterswijk; Daryl A. Bosco; Ildefonso Rodriguez-Leyva; Cinzia Gellera; Antonia Ratti; Franco Taroni; Diane McKenna-Yasek; Peter C. Sapp; Vincenzo Silani; Clement E. Furlong; Robert H. Brown; John E. Landers

doi:10.1002/ana.21993

Paraoxonase gene mutations in amyotrophic lateral sclerosis

Nicola Ticozzi, Ashley Lyn LeClerc, Pamela J. Keagle, Jonathan D. Glass, Anne Marie Wills, Marka Van Blitterswijk, Daryl A. Bosco, Ildefonso Rodriguez-Leyva, Cinzia Gellera, Antonia Ratti, Franco Taroni, Diane McKenna-Yasek, Peter C. Sapp, Vincenzo Silani, Clement E. Furlong, Robert H. Brown, John E. Landers

Neuroscience

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.

Original language	English (US)
Pages (from-to)	102-107
Number of pages	6
Journal	Annals of neurology
Volume	68
Issue number	1
DOIs	https://doi.org/10.1002/ana.21993
State	Published - Jul 2010

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Ticozzi, N., LeClerc, A. L., Keagle, P. J., Glass, J. D., Wills, A. M., Van Blitterswijk, M., Bosco, D. A., Rodriguez-Leyva, I., Gellera, C., Ratti, A., Taroni, F., McKenna-Yasek, D., Sapp, P. C., Silani, V., Furlong, C. E., Brown, R. H., & Landers, J. E. (2010). Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of neurology, 68(1), 102-107. https://doi.org/10.1002/ana.21993

Ticozzi, N, LeClerc, AL, Keagle, PJ, Glass, JD, Wills, AM, Van Blitterswijk, M, Bosco, DA, Rodriguez-Leyva, I, Gellera, C, Ratti, A, Taroni, F, McKenna-Yasek, D, Sapp, PC, Silani, V, Furlong, CE, Brown, RH & Landers, JE 2010, 'Paraoxonase gene mutations in amyotrophic lateral sclerosis', Annals of neurology, vol. 68, no. 1, pp. 102-107. https://doi.org/10.1002/ana.21993

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title = "Paraoxonase gene mutations in amyotrophic lateral sclerosis",

abstract = "Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.",

author = "Nicola Ticozzi and LeClerc, {Ashley Lyn} and Keagle, {Pamela J.} and Glass, {Jonathan D.} and Wills, {Anne Marie} and {Van Blitterswijk}, Marka and Bosco, {Daryl A.} and Ildefonso Rodriguez-Leyva and Cinzia Gellera and Antonia Ratti and Franco Taroni and Diane McKenna-Yasek and Sapp, {Peter C.} and Vincenzo Silani and Furlong, {Clement E.} and Brown, {Robert H.} and Landers, {John E.}",

year = "2010",

month = jul,

doi = "10.1002/ana.21993",

language = "English (US)",

volume = "68",

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AU - Ticozzi, Nicola

AU - LeClerc, Ashley Lyn

AU - Keagle, Pamela J.

AU - Glass, Jonathan D.

AU - Wills, Anne Marie

AU - Van Blitterswijk, Marka

AU - Bosco, Daryl A.

AU - Rodriguez-Leyva, Ildefonso

AU - Gellera, Cinzia

AU - Ratti, Antonia

AU - Taroni, Franco

AU - McKenna-Yasek, Diane

AU - Sapp, Peter C.

AU - Silani, Vincenzo

AU - Furlong, Clement E.

AU - Brown, Robert H.

AU - Landers, John E.

PY - 2010/7

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Paraoxonase gene mutations in amyotrophic lateral sclerosis

Abstract

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