Paraoxonase gene mutations in amyotrophic lateral sclerosis

Nicola Ticozzi, Ashley Lyn LeClerc, Pamela J. Keagle, Jonathan D. Glass, Anne Marie Wills, Marka Van Blitterswijk, Daryl A. Bosco, Ildefonso Rodriguez-Leyva, Cinzia Gellera, Antonia Ratti, Franco Taroni, Diane McKenna-Yasek, Peter C. Sapp, Vincenzo Silani, Clement E. Furlong, Robert H. Brown, John E. Landers

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalAnnals of neurology
Volume68
Issue number1
DOIs
StatePublished - Jul 2010

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Ticozzi, N., LeClerc, A. L., Keagle, P. J., Glass, J. D., Wills, A. M., Van Blitterswijk, M., Bosco, D. A., Rodriguez-Leyva, I., Gellera, C., Ratti, A., Taroni, F., McKenna-Yasek, D., Sapp, P. C., Silani, V., Furlong, C. E., Brown, R. H., & Landers, J. E. (2010). Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of neurology, 68(1), 102-107. https://doi.org/10.1002/ana.21993