Paraneoplastic Syndromes Associated With Lung Cancer

ASHOKAKUMAR M. PATEL, DAVID G.DA VILA, STEVE G. PETERS

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Paraneoplastic phenomena associated with primary lung cancer have diverse initial manifestations and epitomize the systemic nature of human malignant disease. The spectrum of clinical features in patients with paraneoplastic syndromes ranges from mild systemic or cutaneous disease to hypercoagulability and severe neuromyopathic disorders. Although the diagnosis is often one of exclusion, an improved understanding of the pathogenesis involved in some of these syndromes has provided another means of recognizing the disorders and perhaps treating the affected patients. Proposed mechanisms of paraneoplastic processes include the aberrant release of humoral mediators such as hormones and hormone-like peptides, cytokines, and antibodies. In this update, we review the potential mechanisms, diagnosis, and treatment of paraneoplastic syndromes associated with lung cancer.

Original languageEnglish (US)
Pages (from-to)278-287
Number of pages10
JournalMayo Clinic proceedings
Volume68
Issue number3
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Medicine(all)

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    PATEL, ASHOKAKUMAR. M., VILA, DAVID. G. DA., & PETERS, STEVE. G. (1993). Paraneoplastic Syndromes Associated With Lung Cancer. Mayo Clinic proceedings, 68(3), 278-287. https://doi.org/10.1016/S0025-6196(12)60050-0