Paraneoplastic Pemphigus: A Case of Prolonged Survival

CHARLES PERNICIARO; MELANIE K. KUECHLE; GERARDO COLÓN-OTERO; MICHAEL G. RAYMOND; KIM L. SPEAR; MARK R. PITTELKOW

doi:10.1016/S0025-6196(12)61787-X

Paraneoplastic Pemphigus: A Case of Prolonged Survival

CHARLES PERNICIARO, MELANIE K. KUECHLE, GERARDO COLÓN-OTERO, MICHAEL G. RAYMOND, KIM L. SPEAR, MARK R. PITTELKOW

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

To describe a patient with severe, recalcitrant mucous membrane erosions and chronic lymphocytic leukemia. We present a case report and a literature review of paraneoplastic pemphigus. Immunofluorescence studies and immunoprecipitation confirmed the presence of autoantibodies characteristic of paraneoplastic pemphigus in the patient's serum. Our patient lived almost 8 years after the onset of paraneoplastic pemphigus, the longest time that anyone with this disease is known to have survived. The clinical course of paraneoplastic pemphigus tends to be rapid and fatal despite immunosuppressive therapy. Long-term survival is uncommon.

Original language	English (US)
Pages (from-to)	851-855
Number of pages	5
Journal	Mayo Clinic proceedings
Volume	69
Issue number	9
DOIs	https://doi.org/10.1016/S0025-6196(12)61787-X
State	Published - Jan 1 1994

ASJC Scopus subject areas

Medicine(all)

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title = "Paraneoplastic Pemphigus: A Case of Prolonged Survival",

abstract = "To describe a patient with severe, recalcitrant mucous membrane erosions and chronic lymphocytic leukemia. We present a case report and a literature review of paraneoplastic pemphigus. Immunofluorescence studies and immunoprecipitation confirmed the presence of autoantibodies characteristic of paraneoplastic pemphigus in the patient's serum. Our patient lived almost 8 years after the onset of paraneoplastic pemphigus, the longest time that anyone with this disease is known to have survived. The clinical course of paraneoplastic pemphigus tends to be rapid and fatal despite immunosuppressive therapy. Long-term survival is uncommon.",

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T2 - A Case of Prolonged Survival

AU - PERNICIARO, CHARLES

AU - KUECHLE, MELANIE K.

AU - COLÓN-OTERO, GERARDO

AU - RAYMOND, MICHAEL G.

AU - SPEAR, KIM L.

AU - PITTELKOW, MARK R.

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N2 - To describe a patient with severe, recalcitrant mucous membrane erosions and chronic lymphocytic leukemia. We present a case report and a literature review of paraneoplastic pemphigus. Immunofluorescence studies and immunoprecipitation confirmed the presence of autoantibodies characteristic of paraneoplastic pemphigus in the patient's serum. Our patient lived almost 8 years after the onset of paraneoplastic pemphigus, the longest time that anyone with this disease is known to have survived. The clinical course of paraneoplastic pemphigus tends to be rapid and fatal despite immunosuppressive therapy. Long-term survival is uncommon.

AB - To describe a patient with severe, recalcitrant mucous membrane erosions and chronic lymphocytic leukemia. We present a case report and a literature review of paraneoplastic pemphigus. Immunofluorescence studies and immunoprecipitation confirmed the presence of autoantibodies characteristic of paraneoplastic pemphigus in the patient's serum. Our patient lived almost 8 years after the onset of paraneoplastic pemphigus, the longest time that anyone with this disease is known to have survived. The clinical course of paraneoplastic pemphigus tends to be rapid and fatal despite immunosuppressive therapy. Long-term survival is uncommon.

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Paraneoplastic Pemphigus: A Case of Prolonged Survival

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