Paraneoplastic pemphigus: A case of prolonged survival

C. Perniciaro, M. K. Kuechle, Gerardo Colon-Otero, M. G. Raymond, K. L. Spear, M. R. Pittelkow

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Abstract

Objective: To describe a patient with severe, recalcitrant mucous membrane erosions and chronic lymphocytic leukemia. Design: We present a case report and a literature review of paraneoplastic pemphigus. Material and Methods: Immunofluorescence studies and immunoprecipitation confirmed the presence of autoantibodies characteristic of paraneoplastic pemphigus in the patient's serum. Results: Our patient lived almost 8 years after the onset of paraneoplastic pemphigus, the longest time that anyone with this disease is known to have survived. Conclusion: The clinical course of paraneoplastic pemphigus tends to be rapid and fatal despite immunosuppressive therapy. Long-term survival is uncommon.

Original languageEnglish (US)
Pages (from-to)851-855
Number of pages5
JournalMayo Clinic Proceedings
Volume69
Issue number9
StatePublished - 1994

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ASJC Scopus subject areas

  • Medicine(all)

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Perniciaro, C., Kuechle, M. K., Colon-Otero, G., Raymond, M. G., Spear, K. L., & Pittelkow, M. R. (1994). Paraneoplastic pemphigus: A case of prolonged survival. Mayo Clinic Proceedings, 69(9), 851-855.