Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung

Madhav R. Thambisetty, Clemens R. Scherzer, Zhiya Yu, Vanda A Lennon, Nancy J. Newman

Research output: Contribution to journalArticle

24 Scopus citations


Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.

Original languageEnglish (US)
Pages (from-to)164-167
Number of pages4
JournalJournal of Neuro-Ophthalmology
Issue number3
StatePublished - 2001



  • Neuro-ophthalmology
  • Neuroimmunology
  • Oncology

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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