Paraneoplastic neurological syndromes: clinical presentations and management

Michelle F. Devine, Naga Kothapalli, Mahmoud Elkhooly, Divyanshu Dubey

Research output: Contribution to journalReview articlepeer-review

Abstract

We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations. Recognition of these syndromes and their oncological associations is crucial, as early diagnosis and management has been associated with better patient outcomes. Specific management strategies and prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information can help tailor treatment approaches. We provide an outline of the diagnostic evaluation and treatment of various paraneoplastic neurological disorders, presenting with central and/or peripheral nervous system involvement. We briefly discuss neurologic immune checkpoint inhibitor-related adverse events, which can occasionally present with paraneoplastic neurological syndrome phenotypes.

Original languageEnglish (US)
JournalTherapeutic Advances in Neurological Disorders
Volume14
DOIs
StatePublished - 2021

Keywords

  • Paraneoplastic neurological syndrome
  • immune checkpoint inhibitor
  • onconeural antibodies
  • paraneoplastic neurological disorder

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology

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