TY - JOUR
T1 - Paraneoplastic neurological syndromes
T2 - clinical presentations and management
AU - Devine, Michelle F.
AU - Kothapalli, Naga
AU - Elkhooly, Mahmoud
AU - Dubey, Divyanshu
N1 - Publisher Copyright:
© The Author(s), 2021.
PY - 2021
Y1 - 2021
N2 - We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations. Recognition of these syndromes and their oncological associations is crucial, as early diagnosis and management has been associated with better patient outcomes. Specific management strategies and prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information can help tailor treatment approaches. We provide an outline of the diagnostic evaluation and treatment of various paraneoplastic neurological disorders, presenting with central and/or peripheral nervous system involvement. We briefly discuss neurologic immune checkpoint inhibitor-related adverse events, which can occasionally present with paraneoplastic neurological syndrome phenotypes.
AB - We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations. Recognition of these syndromes and their oncological associations is crucial, as early diagnosis and management has been associated with better patient outcomes. Specific management strategies and prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information can help tailor treatment approaches. We provide an outline of the diagnostic evaluation and treatment of various paraneoplastic neurological disorders, presenting with central and/or peripheral nervous system involvement. We briefly discuss neurologic immune checkpoint inhibitor-related adverse events, which can occasionally present with paraneoplastic neurological syndrome phenotypes.
KW - Paraneoplastic neurological syndrome
KW - immune checkpoint inhibitor
KW - onconeural antibodies
KW - paraneoplastic neurological disorder
UR - http://www.scopus.com/inward/record.url?scp=85100589628&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100589628&partnerID=8YFLogxK
U2 - 10.1177/1756286420985323
DO - 10.1177/1756286420985323
M3 - Review article
AN - SCOPUS:85100589628
SN - 1756-2856
VL - 14
JO - Therapeutic Advances in Neurological Disorders
JF - Therapeutic Advances in Neurological Disorders
ER -