Paraneoplastic Myelopathy

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Paraneoplastic causes are a rare but important diagnostic consideration when evaluating myelopathy because neurologic symptoms may herald a diagnosis of cancer. Spinal cord MRI findings of longitudinally extensive, symmetric, tract-specific T2-signal changes occasionally with gadolinium enhancement are characteristic. Detection of neural-specific autoantibodies assists in confirming the diagnosis and guides the cancer search. Initial management involves detection and treatment of the underlying cancer. Combinations of immunotherapies are typically recommended but evidence-based therapeutic guidelines are lacking and morbidity remains high. Autoimmune myelopathies may also occur in association with neural-specific autoantibodies without an underlying cancer and in association with systemic autoimmune disorders.

Original languageEnglish (US)
Pages (from-to)307-318
Number of pages12
JournalNeurologic clinics
Volume31
Issue number1
DOIs
StatePublished - Feb 1 2013

Keywords

  • Autoimmune
  • Myelopathy
  • Paraneoplastic
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology

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