Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies

Shamsuddin Khwaja; Naganand Sripathi; B. K. Ahmad; Vanda A. Lennon

doi:10.1002/(SICI)1097-4598(199807)21:7<943::AID-MUS14>3.0.CO;2-R

Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies

Shamsuddin Khwaja, Naganand Sripathi, B. K. Ahmad, Vanda A. Lennon

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67-year-old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti-Yo antibody) was detected in the serum diluted at 1:61,400.

Original language	English (US)
Pages (from-to)	943-945
Number of pages	3
Journal	Muscle and Nerve
Volume	21
Issue number	7
DOIs	https://doi.org/10.1002/(SICI)1097-4598(199807)21:7<943::AID-MUS14>3.0.CO;2-R
State	Published - Jul 1998

Keywords

Anti-Yo
Motor neuron disease
Ovarian cancer
Paraneoplastic
Type 1 Purkinje cell antibodies

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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AB - Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67-year-old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti-Yo antibody) was detected in the serum diluted at 1:61,400.

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Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies

Abstract

Keywords

ASJC Scopus subject areas

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