Paraneoplastic lower motor neuronopathy associated with Hodgkin lymphoma

Eoin Flanagan, Paola Sandroni, Sean J Pittock, David J. Inwards, Lyell Jones

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Paraneoplastic lower motor neuronopathies have been reported rarely with Hodgkin lymphoma. Methods: We report a case of rapidly progressive motor neuronopathy preceding the diagnosis of Hodgkin lymphoma. Results: A 31-year-old woman developed subacute rapidly progressive quadriparesis. Electrodiagnostic studies revealed a severe diffuse disorder of motor neurons and their axons. Symmetric enhancement of the cauda equina motor nerve roots was notable on magnetic resonance imaging scan. Further imaging demonstrated an enlarged supraclavicular lymph node, and biopsy revealed Hodgkin lymphoma. A final diagnosis of paraneoplastic motor neuronopathy was made after investigations for alternative causes of motor neuronopathy were unrevealing. Neurological improvement was seen with combined treatment of the underlying malignancy and intravenous immunoglobulin. Conclusions: Paraneoplastic causes should be considered in the differential diagnosis of subacute motor neuronopathy, as the neurological presentation may precede cancer detection. Combinations of lymphoma treatment and immunotherapy may result in a favorable outcome.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalMuscle and Nerve
Volume46
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

Hodgkin Disease
Cauda Equina
Quadriplegia
Intravenous Immunoglobulins
Motor Neurons
Immunotherapy
Axons
Lymphoma
Neoplasms
Differential Diagnosis
Lymph Nodes
Magnetic Resonance Imaging
Biopsy
Therapeutics

Keywords

  • Hodgkin lymphoma
  • Motor neuron disease
  • Motor neuropathy
  • Paraneoplastic
  • Polyradiculopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

Paraneoplastic lower motor neuronopathy associated with Hodgkin lymphoma. / Flanagan, Eoin; Sandroni, Paola; Pittock, Sean J; Inwards, David J.; Jones, Lyell.

In: Muscle and Nerve, Vol. 46, No. 5, 11.2012, p. 823-827.

Research output: Contribution to journalArticle

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