Paraneoplastic dysmotility: Loss of interstitial cells of Cajal

Darrell S. Pardi, Steven M. Miller, Daniel L. Miller, Lawrence J. Burgart, Joseph H. Szurszewski, Vanda A Lennon, Gianrico Farrugia

Research output: Contribution to journalArticle

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Abstract

Autoimmune impairment and destruction of the enteric nervous plexus are thought to play a central role in the pathogenesis of paraneoplastic motility disorders. We present a case of a small-cell lung carcinoma-related paraneoplastic motility disorder associated with abnormal interstitial cells of Cajal networks. Antibodies against c-Kit and protein gene product 9.5 were used to selectively stain interstitial cells of Cajal and the enteric nervous plexus, respectively. A 68-yr-old man presented with anorexia, early satiety, nausea, and weight loss. Investigations revealed gastroparesis, delayed small intestinal transit, and mediastinal lymphadenopathy. The patient was seropositive for type 1 antineuronal nuclear autoantibody and P/Q-type calcium channel antibody. Biopsy of mediastinal lymph nodes revealed metastatic small-cell carcinoma cells that were immunoreactive for c-Kit. Immunohistochemical staining of a full-thickness small intestinal biopsy revealed a relatively intact myenteric plexus but a sparse and disorganized interstitial cells of Cajal network. The histopathology of this case suggests that interstitial cells of Cajal may be a target in the pathogenesis of paraneoplastic motility disorders.

Original languageEnglish (US)
Pages (from-to)1828-1833
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume97
Issue number7
DOIs
StatePublished - 2002

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Interstitial Cells of Cajal
Q-Type Calcium Channels
P-Type Calcium Channels
Proto-Oncogene Proteins c-kit
Gastroparesis
Biopsy
Myenteric Plexus
Small Cell Carcinoma
Antibodies
Small Cell Lung Carcinoma
Anorexia
Autoantibodies
Nausea
Weight Loss
Coloring Agents
Lymph Nodes
Staining and Labeling
Proteins

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Paraneoplastic dysmotility : Loss of interstitial cells of Cajal. / Pardi, Darrell S.; Miller, Steven M.; Miller, Daniel L.; Burgart, Lawrence J.; Szurszewski, Joseph H.; Lennon, Vanda A; Farrugia, Gianrico.

In: American Journal of Gastroenterology, Vol. 97, No. 7, 2002, p. 1828-1833.

Research output: Contribution to journalArticle

Pardi, Darrell S. ; Miller, Steven M. ; Miller, Daniel L. ; Burgart, Lawrence J. ; Szurszewski, Joseph H. ; Lennon, Vanda A ; Farrugia, Gianrico. / Paraneoplastic dysmotility : Loss of interstitial cells of Cajal. In: American Journal of Gastroenterology. 2002 ; Vol. 97, No. 7. pp. 1828-1833.
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