Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model

Clifford R. Berry, Pradeep K. Garg, Timothy R DeGrado, Peter Hellyer, William Weber, Sudha Garg, Bernard Hansen, Michael R. Zalutsky, R. Edward Coleman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The kinetics of para-[18F]fluorobenzylguanidine ([18F]PFBG) were investigated in a canine coronary artery occlusion model. Methods and Results: Five dogs were imaged by positron emission tomography (PET) before and after complete surgical ligation of the left anterior descending coronary artery. PET studies included a 10-minute dynamic [13N]NH3 perfusion scan, followed 1 hour later by 3-hour dynamic [18F]PFBG scanning. [18F]PFBG and [13N]NH3 images demonstrated homogeneous myocardial uptake/perfusion before infarction. One hundred eighty minutes after [18F]PFBG administration, myocardial accumulation was decreased by 60% (day, 2, 0.0065% ±0.0015% injected dose/ml) and 58% (day 16, 0.0069%±0.003% injected dose/ml) compared with a similar myocardial region of interest from the preinfarction (0.016%±0.005% injected dose/ml) study. Myocardial accumulation of [13N]NH3 at 9 minutes showed a 52% (day 2) and 7% (day 16) decrease compared with the preinfarction study. The accumulation of [18F]PFBG in the infarction was decreased significantly at 120 and 180 minutes on all postinfarction studies (p=0.01). In three dogs a significant decrease in the myocardial norepinephrine concentration was documented in the area of infarction (237±94 ng/gm) versus the noninfarcted (1018±48 ng/gm) myocardium (p=0.001). Conclusions: A decreased accumulation of [18F]PFBG was observed in the area of myocardial infarct in this canine model. The magnitude of the decrease in [18F]PFBG was larger than that seen with [13N]NH3 on day 16 after infarction suggesting reperfusion and persistent sympathetic neuronal dysfunction.

Original languageEnglish (US)
Pages (from-to)119-129
Number of pages11
JournalJournal of Nuclear Cardiology
Volume3
Issue number2
DOIs
StatePublished - Mar 1996
Externally publishedYes

Fingerprint

Coronary Occlusion
Canidae
Coronary Vessels
Infarction
Positron-Emission Tomography
Perfusion
Dogs
4-fluorobenzylguanidine
Reperfusion
Ligation
Myocardium
Norepinephrine
Myocardial Infarction

Keywords

  • canine
  • myocardial
  • para-[F]fluorobenzylguanidine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model. / Berry, Clifford R.; Garg, Pradeep K.; DeGrado, Timothy R; Hellyer, Peter; Weber, William; Garg, Sudha; Hansen, Bernard; Zalutsky, Michael R.; Edward Coleman, R.

In: Journal of Nuclear Cardiology, Vol. 3, No. 2, 03.1996, p. 119-129.

Research output: Contribution to journalArticle

Berry, CR, Garg, PK, DeGrado, TR, Hellyer, P, Weber, W, Garg, S, Hansen, B, Zalutsky, MR & Edward Coleman, R 1996, 'Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model', Journal of Nuclear Cardiology, vol. 3, no. 2, pp. 119-129. https://doi.org/10.1016/S1071-3581(96)90004-5
Berry, Clifford R. ; Garg, Pradeep K. ; DeGrado, Timothy R ; Hellyer, Peter ; Weber, William ; Garg, Sudha ; Hansen, Bernard ; Zalutsky, Michael R. ; Edward Coleman, R. / Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model. In: Journal of Nuclear Cardiology. 1996 ; Vol. 3, No. 2. pp. 119-129.
@article{dcca041d7467492d90f158314f0595b5,
title = "Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model",
abstract = "Background: The kinetics of para-[18F]fluorobenzylguanidine ([18F]PFBG) were investigated in a canine coronary artery occlusion model. Methods and Results: Five dogs were imaged by positron emission tomography (PET) before and after complete surgical ligation of the left anterior descending coronary artery. PET studies included a 10-minute dynamic [13N]NH3 perfusion scan, followed 1 hour later by 3-hour dynamic [18F]PFBG scanning. [18F]PFBG and [13N]NH3 images demonstrated homogeneous myocardial uptake/perfusion before infarction. One hundred eighty minutes after [18F]PFBG administration, myocardial accumulation was decreased by 60{\%} (day, 2, 0.0065{\%} ±0.0015{\%} injected dose/ml) and 58{\%} (day 16, 0.0069{\%}±0.003{\%} injected dose/ml) compared with a similar myocardial region of interest from the preinfarction (0.016{\%}±0.005{\%} injected dose/ml) study. Myocardial accumulation of [13N]NH3 at 9 minutes showed a 52{\%} (day 2) and 7{\%} (day 16) decrease compared with the preinfarction study. The accumulation of [18F]PFBG in the infarction was decreased significantly at 120 and 180 minutes on all postinfarction studies (p=0.01). In three dogs a significant decrease in the myocardial norepinephrine concentration was documented in the area of infarction (237±94 ng/gm) versus the noninfarcted (1018±48 ng/gm) myocardium (p=0.001). Conclusions: A decreased accumulation of [18F]PFBG was observed in the area of myocardial infarct in this canine model. The magnitude of the decrease in [18F]PFBG was larger than that seen with [13N]NH3 on day 16 after infarction suggesting reperfusion and persistent sympathetic neuronal dysfunction.",
keywords = "canine, myocardial, para-[F]fluorobenzylguanidine",
author = "Berry, {Clifford R.} and Garg, {Pradeep K.} and DeGrado, {Timothy R} and Peter Hellyer and William Weber and Sudha Garg and Bernard Hansen and Zalutsky, {Michael R.} and {Edward Coleman}, R.",
year = "1996",
month = "3",
doi = "10.1016/S1071-3581(96)90004-5",
language = "English (US)",
volume = "3",
pages = "119--129",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model

AU - Berry, Clifford R.

AU - Garg, Pradeep K.

AU - DeGrado, Timothy R

AU - Hellyer, Peter

AU - Weber, William

AU - Garg, Sudha

AU - Hansen, Bernard

AU - Zalutsky, Michael R.

AU - Edward Coleman, R.

PY - 1996/3

Y1 - 1996/3

N2 - Background: The kinetics of para-[18F]fluorobenzylguanidine ([18F]PFBG) were investigated in a canine coronary artery occlusion model. Methods and Results: Five dogs were imaged by positron emission tomography (PET) before and after complete surgical ligation of the left anterior descending coronary artery. PET studies included a 10-minute dynamic [13N]NH3 perfusion scan, followed 1 hour later by 3-hour dynamic [18F]PFBG scanning. [18F]PFBG and [13N]NH3 images demonstrated homogeneous myocardial uptake/perfusion before infarction. One hundred eighty minutes after [18F]PFBG administration, myocardial accumulation was decreased by 60% (day, 2, 0.0065% ±0.0015% injected dose/ml) and 58% (day 16, 0.0069%±0.003% injected dose/ml) compared with a similar myocardial region of interest from the preinfarction (0.016%±0.005% injected dose/ml) study. Myocardial accumulation of [13N]NH3 at 9 minutes showed a 52% (day 2) and 7% (day 16) decrease compared with the preinfarction study. The accumulation of [18F]PFBG in the infarction was decreased significantly at 120 and 180 minutes on all postinfarction studies (p=0.01). In three dogs a significant decrease in the myocardial norepinephrine concentration was documented in the area of infarction (237±94 ng/gm) versus the noninfarcted (1018±48 ng/gm) myocardium (p=0.001). Conclusions: A decreased accumulation of [18F]PFBG was observed in the area of myocardial infarct in this canine model. The magnitude of the decrease in [18F]PFBG was larger than that seen with [13N]NH3 on day 16 after infarction suggesting reperfusion and persistent sympathetic neuronal dysfunction.

AB - Background: The kinetics of para-[18F]fluorobenzylguanidine ([18F]PFBG) were investigated in a canine coronary artery occlusion model. Methods and Results: Five dogs were imaged by positron emission tomography (PET) before and after complete surgical ligation of the left anterior descending coronary artery. PET studies included a 10-minute dynamic [13N]NH3 perfusion scan, followed 1 hour later by 3-hour dynamic [18F]PFBG scanning. [18F]PFBG and [13N]NH3 images demonstrated homogeneous myocardial uptake/perfusion before infarction. One hundred eighty minutes after [18F]PFBG administration, myocardial accumulation was decreased by 60% (day, 2, 0.0065% ±0.0015% injected dose/ml) and 58% (day 16, 0.0069%±0.003% injected dose/ml) compared with a similar myocardial region of interest from the preinfarction (0.016%±0.005% injected dose/ml) study. Myocardial accumulation of [13N]NH3 at 9 minutes showed a 52% (day 2) and 7% (day 16) decrease compared with the preinfarction study. The accumulation of [18F]PFBG in the infarction was decreased significantly at 120 and 180 minutes on all postinfarction studies (p=0.01). In three dogs a significant decrease in the myocardial norepinephrine concentration was documented in the area of infarction (237±94 ng/gm) versus the noninfarcted (1018±48 ng/gm) myocardium (p=0.001). Conclusions: A decreased accumulation of [18F]PFBG was observed in the area of myocardial infarct in this canine model. The magnitude of the decrease in [18F]PFBG was larger than that seen with [13N]NH3 on day 16 after infarction suggesting reperfusion and persistent sympathetic neuronal dysfunction.

KW - canine

KW - myocardial

KW - para-[F]fluorobenzylguanidine

UR - http://www.scopus.com/inward/record.url?scp=0029664918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029664918&partnerID=8YFLogxK

U2 - 10.1016/S1071-3581(96)90004-5

DO - 10.1016/S1071-3581(96)90004-5

M3 - Article

C2 - 8799237

AN - SCOPUS:0029664918

VL - 3

SP - 119

EP - 129

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 2

ER -