PAPP-A: A promising therapeutic target for healthy longevity

Cheryl A Conover, Claus Oxvig

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity.

Original languageEnglish (US)
JournalAging Cell
DOIs
StateAccepted/In press - 2016

Fingerprint

Pregnancy-Associated Plasma Protein-A
Somatomedins
Somatomedin Receptors
Insulin-Like Growth Factor Binding Proteins
Peptide Hydrolases
Therapeutics

Keywords

  • Aging
  • IGF
  • PAPP-A

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

PAPP-A : A promising therapeutic target for healthy longevity. / Conover, Cheryl A; Oxvig, Claus.

In: Aging Cell, 2016.

Research output: Contribution to journalArticle

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