PAPP-A: A promising therapeutic target for healthy longevity

Cheryl A Conover, Claus Oxvig

Research output: Contribution to journalArticle

7 Scopus citations


Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity.

Original languageEnglish (US)
JournalAging Cell
StateAccepted/In press - 2016



  • Aging
  • IGF
  • PAPP-A

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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