Abstract
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 942-946 |
| Number of pages | 5 |
| Journal | Aging Cell |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2010 |
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Keywords
- Insulin-like growth factor
- Longevity
- PAPP-A knock-out mice
- Pregnancy-associated plasma protein-A
ASJC Scopus subject areas
- Cell Biology
- Aging
Cite this
PAPP-A : A new anti-aging target? / Conover, Cheryl A.
In: Aging Cell, Vol. 9, No. 6, 12.2010, p. 942-946.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PAPP-A
T2 - A new anti-aging target?
AU - Conover, Cheryl A
PY - 2010/12
Y1 - 2010/12
N2 - This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
AB - This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
KW - Insulin-like growth factor
KW - Longevity
KW - PAPP-A knock-out mice
KW - Pregnancy-associated plasma protein-A
UR - http://www.scopus.com/inward/record.url?scp=78249242422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78249242422&partnerID=8YFLogxK
U2 - 10.1111/j.1474-9726.2010.00630.x
DO - 10.1111/j.1474-9726.2010.00630.x
M3 - Article
C2 - 20854420
AN - SCOPUS:78249242422
VL - 9
SP - 942
EP - 946
JO - Aging Cell
JF - Aging Cell
SN - 1474-9718
IS - 6
ER -