PAPP-A: A new anti-aging target?

Cheryl A. Conover

doi:10.1111/j.1474-9726.2010.00630.x

PAPP-A: A new anti-aging target?

Cheryl A. Conover

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.

Original language	English (US)
Pages (from-to)	942-946
Number of pages	5
Journal	Aging Cell
Volume	9
Issue number	6
DOIs	https://doi.org/10.1111/j.1474-9726.2010.00630.x
State	Published - Dec 2010

Keywords

Insulin-like growth factor
Longevity
PAPP-A knock-out mice
Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

Aging
Cell Biology

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title = "PAPP-A: A new anti-aging target?",

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AB - This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.

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KW - Pregnancy-associated plasma protein-A

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PAPP-A: A new anti-aging target?

Abstract

Keywords

ASJC Scopus subject areas

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