Abstract
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 942-946 |
| Number of pages | 5 |
| Journal | Aging Cell |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2010 |
Keywords
- Insulin-like growth factor
- Longevity
- PAPP-A knock-out mice
- Pregnancy-associated plasma protein-A
ASJC Scopus subject areas
- Aging
- Cell Biology