PAPP-A: A new anti-aging target?

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.

Original languageEnglish (US)
Pages (from-to)942-946
Number of pages5
JournalAging Cell
Volume9
Issue number6
DOIs
StatePublished - Dec 2010

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Pregnancy-Associated Plasma Protein-A
Somatomedins
Knockout Mice
History

Keywords

  • Insulin-like growth factor
  • Longevity
  • PAPP-A knock-out mice
  • Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

PAPP-A : A new anti-aging target? / Conover, Cheryl A.

In: Aging Cell, Vol. 9, No. 6, 12.2010, p. 942-946.

Research output: Contribution to journalArticle

Conover, Cheryl A. / PAPP-A : A new anti-aging target?. In: Aging Cell. 2010 ; Vol. 9, No. 6. pp. 942-946.
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