Papillary thyroid microcarcinoma: A study of 535 eases observed in a 5o-year period

Ian D Hay, Clive S. Grant, Jon A. van Heerden, John R. Goellner, Janet R. Ebersold, Erik J. Bergstralh

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Abstract

Background. The study aims were to characterize patients with papillary thyroid microcarcinoma and to provide data on outcome after surgical therapy. Methods. Five hundred thirty-five patients with papillary microcarcinoma had initial treatment at Mayo Clinic from 1940 to 1989. Follow-up extended to 48 years. Median follow-up time for 400 survivors was 16 years. Recurrence and mortality details were derived from a computerized cancer database. Results. Median tumor size was 8 mm. Ninety-nine percent of tumors were histologic grade 1; 98% were not locally invasive. Thirty-two percent of patients had nodal metastases at examination. TNM stages were I in 485 patients (91%), III in 49 patients (9%), and IV in one patient (0.2%). Ninety-one percent of patients underwent bilateral lobar resection. Tumor resection was incomplete in three cases (0.6%). Radioiodine remnant ablation was performed in 55 patients (10%). All-causes survival did not differ from expected; two patients (0.4%) died of papillary microcarcinoma. Twenty-year tumor recurrence rate was 6%. Higher recurrence rates were seen either with node-positive patients (p < 0.0001) or after unilateral lobectomy (p < 0.0001). Recurrence rates did not appear to be significantly altered by total thyroidectomy (p = 0.44) or radioiodine remnant ablation in node-positive patients (p = 0.99). Conclusions. These results reaffirm that papillary microcarcinoma has an excellent prognosis if managed initially by bilateral lobar resection. Routine radio' odine remnant ablation is not indicated.

Original languageEnglish (US)
Pages (from-to)1139-1147
Number of pages9
JournalSurgery
Volume112
Issue number6
StatePublished - 1992

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Recurrence
Neoplasms
Papillary Thyroid Microcarcinoma
Thyroidectomy
Radio
Survivors
Databases
Neoplasm Metastasis
Survival
Mortality
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Hay, I. D., Grant, C. S., van Heerden, J. A., Goellner, J. R., Ebersold, J. R., & Bergstralh, E. J. (1992). Papillary thyroid microcarcinoma: A study of 535 eases observed in a 5o-year period. Surgery, 112(6), 1139-1147.

Papillary thyroid microcarcinoma : A study of 535 eases observed in a 5o-year period. / Hay, Ian D; Grant, Clive S.; van Heerden, Jon A.; Goellner, John R.; Ebersold, Janet R.; Bergstralh, Erik J.

In: Surgery, Vol. 112, No. 6, 1992, p. 1139-1147.

Research output: Contribution to journalArticle

Hay, ID, Grant, CS, van Heerden, JA, Goellner, JR, Ebersold, JR & Bergstralh, EJ 1992, 'Papillary thyroid microcarcinoma: A study of 535 eases observed in a 5o-year period', Surgery, vol. 112, no. 6, pp. 1139-1147.
Hay ID, Grant CS, van Heerden JA, Goellner JR, Ebersold JR, Bergstralh EJ. Papillary thyroid microcarcinoma: A study of 535 eases observed in a 5o-year period. Surgery. 1992;112(6):1139-1147.
Hay, Ian D ; Grant, Clive S. ; van Heerden, Jon A. ; Goellner, John R. ; Ebersold, Janet R. ; Bergstralh, Erik J. / Papillary thyroid microcarcinoma : A study of 535 eases observed in a 5o-year period. In: Surgery. 1992 ; Vol. 112, No. 6. pp. 1139-1147.
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