Pancytopenia due to bone marrow necrosis in acute myelogenous leukemia: Role of reactive CD8 cells

S. N. Markovic, R. L. Phyliky, C. Y. Li

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work-up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML- M2 blasts. The role of Tc bone scans in the work-up of bone marrow necrosis as well as the potential mechanism of AML-M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalAmerican journal of hematology
Volume59
Issue number1
DOIs
StatePublished - Sep 1 1998

Keywords

  • Acute myelogenous leukemia
  • Bone marrow necrosis
  • Bone scan
  • CD8+ T cells

ASJC Scopus subject areas

  • Hematology

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