Pancreatoduodenectomy for ductal adenocarcinoma: Implications of positive margin on survival

Javairiah Fatima, Thomas Schnelldorfer, Joshua Barton, Christina M. Wood, Heather J. Wiste, Thomas Christopher Smyrk, Lizhi Zhang, Michael G. Sarr, David M. Nagorney, Michael B. Farnell

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective: To assess the effect of R0 resection margin status and R0 en bloc resection in pancreatoduodenectomy outcomes. Design: Retrospective medical record review. Setting: Mayo Clinic, Rochester, Minnesota. Patients: Patients who underwent pancreatoduodenectomy for pancreatic adenocarcinoma at our institution between January 1, 1981, and December 31, 2007, were identified and their medical records were reviewed. Main Outcome Measure: Median survival times. Results: A total of 617 patients underwent pancreatoduodenectomy. Median survival times after R0 en bloc resection (n=411), R0 non-en bloc resection (n=57), R1 resection (n=127), and R2 resection (n=22) were 19, 18, 15, and 10 months, respectively (P<.001). A positive resection margin was associated with death (P=.01). No difference in survival time was found between patients undergoing R0 en bloc and R0 resections after reexcision of an initial positive margin (hazard ratio, 1.19; 95% confidence interval, 0.87-1.64; P=.28). Conclusions: R0 resection remains an important prognostic factor. Achieving R0 status by initial en bloc resection or reexcision results in similar long-term survival.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalArchives of Surgery
Volume145
Issue number2
DOIs
StatePublished - Feb 2010

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Pancreaticoduodenectomy
Adenocarcinoma
Survival
Medical Records
Outcome Assessment (Health Care)
Confidence Intervals
Margins of Excision

ASJC Scopus subject areas

  • Surgery

Cite this

Fatima, J., Schnelldorfer, T., Barton, J., Wood, C. M., Wiste, H. J., Smyrk, T. C., ... Farnell, M. B. (2010). Pancreatoduodenectomy for ductal adenocarcinoma: Implications of positive margin on survival. Archives of Surgery, 145(2), 167-172. https://doi.org/10.1001/archsurg.2009.282

Pancreatoduodenectomy for ductal adenocarcinoma : Implications of positive margin on survival. / Fatima, Javairiah; Schnelldorfer, Thomas; Barton, Joshua; Wood, Christina M.; Wiste, Heather J.; Smyrk, Thomas Christopher; Zhang, Lizhi; Sarr, Michael G.; Nagorney, David M.; Farnell, Michael B.

In: Archives of Surgery, Vol. 145, No. 2, 02.2010, p. 167-172.

Research output: Contribution to journalArticle

Fatima, J, Schnelldorfer, T, Barton, J, Wood, CM, Wiste, HJ, Smyrk, TC, Zhang, L, Sarr, MG, Nagorney, DM & Farnell, MB 2010, 'Pancreatoduodenectomy for ductal adenocarcinoma: Implications of positive margin on survival', Archives of Surgery, vol. 145, no. 2, pp. 167-172. https://doi.org/10.1001/archsurg.2009.282
Fatima, Javairiah ; Schnelldorfer, Thomas ; Barton, Joshua ; Wood, Christina M. ; Wiste, Heather J. ; Smyrk, Thomas Christopher ; Zhang, Lizhi ; Sarr, Michael G. ; Nagorney, David M. ; Farnell, Michael B. / Pancreatoduodenectomy for ductal adenocarcinoma : Implications of positive margin on survival. In: Archives of Surgery. 2010 ; Vol. 145, No. 2. pp. 167-172.
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