Pancreatitis before pancreatic cancer clinical features and influence on outcome

Ivana Dzeletovic, M. Edwyn Harrison, Michael D. Crowell, Rahul Pannala, Cuong C Nguyen, Qing Wu, Douglas Orrick Faigel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: Pancreatitis is considered a possible risk factor for and a presentation of pancreatic adenocarcinoma (PA). We aimed to evaluate a large PA patient registry to determine whether prior history of pancreatitis influenced survival. Methods: We retrospectively analyzed the Mayo Clinic Biospecimen Resource for Pancreas Research database from January 1992 to September 2011. Data collected included demographic characteristics, history of tobacco or alcohol use, diabetes mellitus (DM), cholelithiasis, pseudocyst, and details regarding PA. Clinical characteristics and outcomes of PA patients with pancreatitis were compared with PA patients without pancreatitis history. Results: We analyzed 2573 patients with PA diagnosis. Among these patients, 195 (8%) were identified who had pancreatitis diagnosis ≥10 days before PA diagnosis. The cohort with pancreatitis history included more patients with DM (30% vs. 18%; P:lt;0.001) and more smokers (68% vs. 58%; P=0.02). Compared with patients without pancreatitis history, these patients received diagnoses of PA at a younger age (63 vs. 65 y; P=0.005) and earlier stage (stages I and II; 52% vs. 37%; P≤0.001). A greater percentage had history of surgery with curative intent (50% vs. 43%; P=0.001) and significantly better survival [median (range), 387 d (314 to 460 d) vs. 325 d (306 to 344 d); P=0.003]. Conclusions: Patients with PA and pancreatitis had more weight loss and DM, but had PA diagnosis at an earlier stage, were more likely to have pancreatic surgery, and therefore better survival than PA patients without pancreatitis, likely due to the earlier diagnosis. Further studies are needed to evaluate whether screening for PA in patients with pancreatitis history would provide survival benefit.

Original languageEnglish (US)
Pages (from-to)801-805
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume48
Issue number9
StatePublished - Oct 1 2014

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Pancreatic Neoplasms
Pancreatitis
Adenocarcinoma
Diabetes Mellitus
Survival
Cholelithiasis
Tobacco
Registries
Weight Loss
Early Diagnosis
Pancreas
Alcohols
Demography
Databases

Keywords

  • Pancreatic adenocarcinoma
  • Pancreatitis
  • Survival analysis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pancreatitis before pancreatic cancer clinical features and influence on outcome. / Dzeletovic, Ivana; Harrison, M. Edwyn; Crowell, Michael D.; Pannala, Rahul; Nguyen, Cuong C; Wu, Qing; Faigel, Douglas Orrick.

In: Journal of Clinical Gastroenterology, Vol. 48, No. 9, 01.10.2014, p. 801-805.

Research output: Contribution to journalArticle

Dzeletovic, Ivana ; Harrison, M. Edwyn ; Crowell, Michael D. ; Pannala, Rahul ; Nguyen, Cuong C ; Wu, Qing ; Faigel, Douglas Orrick. / Pancreatitis before pancreatic cancer clinical features and influence on outcome. In: Journal of Clinical Gastroenterology. 2014 ; Vol. 48, No. 9. pp. 801-805.
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abstract = "Objectives: Pancreatitis is considered a possible risk factor for and a presentation of pancreatic adenocarcinoma (PA). We aimed to evaluate a large PA patient registry to determine whether prior history of pancreatitis influenced survival. Methods: We retrospectively analyzed the Mayo Clinic Biospecimen Resource for Pancreas Research database from January 1992 to September 2011. Data collected included demographic characteristics, history of tobacco or alcohol use, diabetes mellitus (DM), cholelithiasis, pseudocyst, and details regarding PA. Clinical characteristics and outcomes of PA patients with pancreatitis were compared with PA patients without pancreatitis history. Results: We analyzed 2573 patients with PA diagnosis. Among these patients, 195 (8{\%}) were identified who had pancreatitis diagnosis ≥10 days before PA diagnosis. The cohort with pancreatitis history included more patients with DM (30{\%} vs. 18{\%}; P:lt;0.001) and more smokers (68{\%} vs. 58{\%}; P=0.02). Compared with patients without pancreatitis history, these patients received diagnoses of PA at a younger age (63 vs. 65 y; P=0.005) and earlier stage (stages I and II; 52{\%} vs. 37{\%}; P≤0.001). A greater percentage had history of surgery with curative intent (50{\%} vs. 43{\%}; P=0.001) and significantly better survival [median (range), 387 d (314 to 460 d) vs. 325 d (306 to 344 d); P=0.003]. Conclusions: Patients with PA and pancreatitis had more weight loss and DM, but had PA diagnosis at an earlier stage, were more likely to have pancreatic surgery, and therefore better survival than PA patients without pancreatitis, likely due to the earlier diagnosis. Further studies are needed to evaluate whether screening for PA in patients with pancreatitis history would provide survival benefit.",
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AU - Wu, Qing

AU - Faigel, Douglas Orrick

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AB - Objectives: Pancreatitis is considered a possible risk factor for and a presentation of pancreatic adenocarcinoma (PA). We aimed to evaluate a large PA patient registry to determine whether prior history of pancreatitis influenced survival. Methods: We retrospectively analyzed the Mayo Clinic Biospecimen Resource for Pancreas Research database from January 1992 to September 2011. Data collected included demographic characteristics, history of tobacco or alcohol use, diabetes mellitus (DM), cholelithiasis, pseudocyst, and details regarding PA. Clinical characteristics and outcomes of PA patients with pancreatitis were compared with PA patients without pancreatitis history. Results: We analyzed 2573 patients with PA diagnosis. Among these patients, 195 (8%) were identified who had pancreatitis diagnosis ≥10 days before PA diagnosis. The cohort with pancreatitis history included more patients with DM (30% vs. 18%; P:lt;0.001) and more smokers (68% vs. 58%; P=0.02). Compared with patients without pancreatitis history, these patients received diagnoses of PA at a younger age (63 vs. 65 y; P=0.005) and earlier stage (stages I and II; 52% vs. 37%; P≤0.001). A greater percentage had history of surgery with curative intent (50% vs. 43%; P=0.001) and significantly better survival [median (range), 387 d (314 to 460 d) vs. 325 d (306 to 344 d); P=0.003]. Conclusions: Patients with PA and pancreatitis had more weight loss and DM, but had PA diagnosis at an earlier stage, were more likely to have pancreatic surgery, and therefore better survival than PA patients without pancreatitis, likely due to the earlier diagnosis. Further studies are needed to evaluate whether screening for PA in patients with pancreatitis history would provide survival benefit.

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