Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: Real association or just a coincidence?

Kanwar Rupinder S Gill, Daniela Scimeca, John Stauffer, Murli Krishna, Timothy A. Woodward, Laith H. Jamil, Michael B. Wallace, Justin H Nguyen, Massimo Raimondo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Context: Intraductal papillary mucinous neoplasms (IPMNs) are being recognized with increased frequency and are the most common indication of pancreatic surgery at specialized centers. Many IPMN patients are found to have non-IPMN related pancreatic tumors like pancreatic neuroendocrine tumors (PNTs). Objective: To study the prevalence of PNTs among patients with IPMN. Methods: Patients who underwent surgical resection for IPMN were retrospectively reviewed for presence of histologically proven PNTs. The PNTs were evaluated for the patient demographics, imaging characteristics, histology, and surgical staging. Results: Between January 2002 and October 2007, 104 patients underwent surgery for pancreatic IPMN. Among these, 4 patients (3.8%) were diagnosed with concomitant PNTs (1 male, 3 females; median age 72 years). Three patients had branch duct type-IPMN (cyst size: 19 mm, 15 mm and 27 mm), and one had main duct type-IPMN. Only one branch duct IPMN had adenocarcinoma, other three had low grade/borderline dysplasia. The median size of PNT was 10 mm (range 8-16 mm) and all were missed on the cross sectional imaging. Three patients were recognized by endoscopic ultrasound (EUS) and the fine needle aspiration confirmed the diagnosis in 1/3. Only one patient had metastatic PNT to lymph node, the other three were low grade lesions. Conclusion: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association.

Original languageEnglish (US)
Pages (from-to)515-517
Number of pages3
JournalJournal of the Pancreas
Volume10
Issue number5
StatePublished - 2009

Fingerprint

Neuroendocrine Tumors
Neoplasms
Pancreatic Neoplasms
Fine Needle Biopsy
Sample Size
Cysts
Histology
Adenocarcinoma
Cross-Sectional Studies
Lymph Nodes
Demography

Keywords

  • Endosonography
  • Neuroendocrine tumors
  • Pancreatic diseases

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

Cite this

Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms : Real association or just a coincidence? / Gill, Kanwar Rupinder S; Scimeca, Daniela; Stauffer, John; Krishna, Murli; Woodward, Timothy A.; Jamil, Laith H.; Wallace, Michael B.; Nguyen, Justin H; Raimondo, Massimo.

In: Journal of the Pancreas, Vol. 10, No. 5, 2009, p. 515-517.

Research output: Contribution to journalArticle

Gill, KRS, Scimeca, D, Stauffer, J, Krishna, M, Woodward, TA, Jamil, LH, Wallace, MB, Nguyen, JH & Raimondo, M 2009, 'Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: Real association or just a coincidence?', Journal of the Pancreas, vol. 10, no. 5, pp. 515-517.
Gill, Kanwar Rupinder S ; Scimeca, Daniela ; Stauffer, John ; Krishna, Murli ; Woodward, Timothy A. ; Jamil, Laith H. ; Wallace, Michael B. ; Nguyen, Justin H ; Raimondo, Massimo. / Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms : Real association or just a coincidence?. In: Journal of the Pancreas. 2009 ; Vol. 10, No. 5. pp. 515-517.
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abstract = "Context: Intraductal papillary mucinous neoplasms (IPMNs) are being recognized with increased frequency and are the most common indication of pancreatic surgery at specialized centers. Many IPMN patients are found to have non-IPMN related pancreatic tumors like pancreatic neuroendocrine tumors (PNTs). Objective: To study the prevalence of PNTs among patients with IPMN. Methods: Patients who underwent surgical resection for IPMN were retrospectively reviewed for presence of histologically proven PNTs. The PNTs were evaluated for the patient demographics, imaging characteristics, histology, and surgical staging. Results: Between January 2002 and October 2007, 104 patients underwent surgery for pancreatic IPMN. Among these, 4 patients (3.8{\%}) were diagnosed with concomitant PNTs (1 male, 3 females; median age 72 years). Three patients had branch duct type-IPMN (cyst size: 19 mm, 15 mm and 27 mm), and one had main duct type-IPMN. Only one branch duct IPMN had adenocarcinoma, other three had low grade/borderline dysplasia. The median size of PNT was 10 mm (range 8-16 mm) and all were missed on the cross sectional imaging. Three patients were recognized by endoscopic ultrasound (EUS) and the fine needle aspiration confirmed the diagnosis in 1/3. Only one patient had metastatic PNT to lymph node, the other three were low grade lesions. Conclusion: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8{\%}). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association.",
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AU - Gill, Kanwar Rupinder S

AU - Scimeca, Daniela

AU - Stauffer, John

AU - Krishna, Murli

AU - Woodward, Timothy A.

AU - Jamil, Laith H.

AU - Wallace, Michael B.

AU - Nguyen, Justin H

AU - Raimondo, Massimo

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N2 - Context: Intraductal papillary mucinous neoplasms (IPMNs) are being recognized with increased frequency and are the most common indication of pancreatic surgery at specialized centers. Many IPMN patients are found to have non-IPMN related pancreatic tumors like pancreatic neuroendocrine tumors (PNTs). Objective: To study the prevalence of PNTs among patients with IPMN. Methods: Patients who underwent surgical resection for IPMN were retrospectively reviewed for presence of histologically proven PNTs. The PNTs were evaluated for the patient demographics, imaging characteristics, histology, and surgical staging. Results: Between January 2002 and October 2007, 104 patients underwent surgery for pancreatic IPMN. Among these, 4 patients (3.8%) were diagnosed with concomitant PNTs (1 male, 3 females; median age 72 years). Three patients had branch duct type-IPMN (cyst size: 19 mm, 15 mm and 27 mm), and one had main duct type-IPMN. Only one branch duct IPMN had adenocarcinoma, other three had low grade/borderline dysplasia. The median size of PNT was 10 mm (range 8-16 mm) and all were missed on the cross sectional imaging. Three patients were recognized by endoscopic ultrasound (EUS) and the fine needle aspiration confirmed the diagnosis in 1/3. Only one patient had metastatic PNT to lymph node, the other three were low grade lesions. Conclusion: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association.

AB - Context: Intraductal papillary mucinous neoplasms (IPMNs) are being recognized with increased frequency and are the most common indication of pancreatic surgery at specialized centers. Many IPMN patients are found to have non-IPMN related pancreatic tumors like pancreatic neuroendocrine tumors (PNTs). Objective: To study the prevalence of PNTs among patients with IPMN. Methods: Patients who underwent surgical resection for IPMN were retrospectively reviewed for presence of histologically proven PNTs. The PNTs were evaluated for the patient demographics, imaging characteristics, histology, and surgical staging. Results: Between January 2002 and October 2007, 104 patients underwent surgery for pancreatic IPMN. Among these, 4 patients (3.8%) were diagnosed with concomitant PNTs (1 male, 3 females; median age 72 years). Three patients had branch duct type-IPMN (cyst size: 19 mm, 15 mm and 27 mm), and one had main duct type-IPMN. Only one branch duct IPMN had adenocarcinoma, other three had low grade/borderline dysplasia. The median size of PNT was 10 mm (range 8-16 mm) and all were missed on the cross sectional imaging. Three patients were recognized by endoscopic ultrasound (EUS) and the fine needle aspiration confirmed the diagnosis in 1/3. Only one patient had metastatic PNT to lymph node, the other three were low grade lesions. Conclusion: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association.

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