Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

Barham K Abu Dayyeh, Darwin Conwell, Navtej Singh Buttar, Vivek Kadilaya, Philip A. Hart, Nikola A. Baumann, Benjamin L. Bick, Suresh T Chari, Sonia Chowdhary, Jonathan E. Clain, Ferga C. Gleeson, Linda S. Lee, Michael J. Levy, Randall K. Pearson, Bret Thomas Petersen, Elizabeth Rajan, Hanno Steen, Shadeah Suleiman, Peter A. Banks, Santhi Swaroop VegeMark Topazian

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Abstract

Objectives: Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease. Methods: We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants. Results: Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P ≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations. Conclusions: PJ PGE2 appears to be a biomarker for CP and is elevated in both established and "minimal change" chronic pancreatitis.

Original languageEnglish (US)
Article numbere72
JournalClinical and Translational Gastroenterology
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2015

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ASJC Scopus subject areas

  • Gastroenterology

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Dayyeh, B. K. A., Conwell, D., Buttar, N. S., Kadilaya, V., Hart, P. A., Baumann, N. A., Bick, B. L., Chari, S. T., Chowdhary, S., Clain, J. E., Gleeson, F. C., Lee, L. S., Levy, M. J., Pearson, R. K., Petersen, B. T., Rajan, E., Steen, H., Suleiman, S., Banks, P. A., ... Topazian, M. (2015). Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease. Clinical and Translational Gastroenterology, 6(1), [e72]. https://doi.org/10.1038/ctg.2014.23