Pancreatic intraepithelial neoplasia in heterotopic pancreas: Evidence for the progression model of pancreatic ductal adenocarcinoma

Lizhi Zhang, Schuyler O. Sanderson, Ricardo V. Lloyd, Thomas Christopher Smyrk

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Morphologic, clinical, and genetic evidence suggests that pancreatic intraepithelial neoplasia (PanIN) is a precursor to ductal adenocarcinoma. But understanding precursor lesions in a pancreas with existing tumor is hampered by the fact that chronic pancreatitis often accompanies carcinoma, and the possible interactions between tumor, chronic pancreatitis, and PanIN are complex. Furthermore, cancerization of ducts can mimic high-grade PanIN. Heterotopic pancreas has a genetic make-up, physiologic function, and local environmental exposure similar to that of the pancreas. It offers an opportunity to study putative precursor lesions in a setting with fewer confounding factors. We identified 6 pancreatic cancer patients who had heterotopic pancreas removed at the time of surgery. All 6 cases were immunostained for p53, cyclin D1, and p16. Molecular analysis of K-ras mutation was also done. All 6 cancer-associated heterotopias had PanIN-1A or 1B; 5 had PanIN-2 and 1 had PanIN-3. Three of 6 cases harbored the same K-ras codon 12 mutation as the PanINs in orthotopic pancreas, and a similar pattern of p53, cyclin D1, and p16 expression was observed between heterotopic and orthotopic pancreas in all 6 cases. There was no chronic pancreatitis in the cancer-associated heterotopias, but chronic pancreatitis was seen adjacent to carcinoma in 5 of 6 cases. The presence of PanIN in heterotopic pancreas from patients with ductal adenocarcinoma supports the progression model.

Original languageEnglish (US)
Pages (from-to)1191-1195
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume31
Issue number8
DOIs
StatePublished - Aug 2007

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Pancreas
Adenocarcinoma
Neoplasms
Chronic Pancreatitis
Cyclin D1
Carcinoma
Mutation
Environmental Exposure
Pancreatic Neoplasms
Codon

Keywords

  • Heterotopic pancreas
  • Pancreatic ductal adenocarcinoma
  • Pancreatic intraepithelial neoplasia

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Pancreatic intraepithelial neoplasia in heterotopic pancreas : Evidence for the progression model of pancreatic ductal adenocarcinoma. / Zhang, Lizhi; Sanderson, Schuyler O.; Lloyd, Ricardo V.; Smyrk, Thomas Christopher.

In: American Journal of Surgical Pathology, Vol. 31, No. 8, 08.2007, p. 1191-1195.

Research output: Contribution to journalArticle

Zhang, Lizhi ; Sanderson, Schuyler O. ; Lloyd, Ricardo V. ; Smyrk, Thomas Christopher. / Pancreatic intraepithelial neoplasia in heterotopic pancreas : Evidence for the progression model of pancreatic ductal adenocarcinoma. In: American Journal of Surgical Pathology. 2007 ; Vol. 31, No. 8. pp. 1191-1195.
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